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Home > Products > Recombinant Proteins > Recombinant Human Breakpoint Cluster Region protein, MYC/DDK-tagged

Recombinant Human Breakpoint Cluster Region protein, MYC/DDK-tagged

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Human(11)
Mouse(2)
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GST(2)
His(1)
MYC/DDK(1)
Cat.No.:
BCR-1543H
Product Overview:
Recombinant Human Breakpoint Cluster Region, transcript variant 2, fused with MYC/DDK tag at C-terminal was expressed in HEK293.
Description:
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Source:
HEK293
Species:
Human
Tag:
MYC/DDK
Form:
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass:
137.5 kDa
Purity:
> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:
>50 ug/mL as determined by microplate BCA method


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Note: There will be extra charge for optional service!
Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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