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Recombinant Human FURIN protein, His-tagged

Cat.No. : FURIN-17H
Product Overview : Human Furin, His Tag is expressed from human 293 cells (HEK293). It contains AA Asp108-Glu715 (Accession # P09958).
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Description : Furin is also known as paired basic Amino acid Cleaving Enzyme (PACE), is an enzyme which belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. The expression of furin in T-cells is required for maintenance of peripheral immune tolerance. Furin cleaves proteins just downstream of a basic amino acid target sequence (canonically, Arg-X-(Arg/Lys) -Arg'). PACE is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. In addition to processing cellular precursor proteins, furin is also utilized by a number of pathogens. For example, the envelope proteins of viruses such as HIV, influenza and dengue fever viruses must be cleaved by furin or furin-like proteases to become fully functional. PACE also play a role in tumor progression.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Asp 108
Form : Lyophilized from 0.22 um filtered solution in 20 mM Tris, 150 mM NaCl, 1 mM CaCl2, 0.01% Birj-35, pH9.0, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 67.5 kDa.
Protein length : Asp108-Glu715
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product MUST be stored at -70°C or lower upon receipt;
-70°C for 3 months under sterile conditions.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μl. Centrifuge the vial at 4°C before opening to recover the entire contents.
Shipping : This product is supplied as sterile liquid solution and shipped frozen with dry ice, please inquire the shipping cost.
Gene Name : FURIN furin, paired basic amino acid cleaving enzyme [Homo sapiens (human)]
Official Symbol : FURIN
Synonyms : FURIN, FUR, PACE, PCSK3, SPC1
Gene ID : 5045
mRNA Refseq : NM_002569
Protein Refseq : NP_002560
MIM : 136950
UniProt ID : P09958

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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10/10/2022

    The proteins purchased from your company are of very high quality and are suitable for WB experiments.

    02/04/2022

      High quality product at a good price, a satisfactory shopping experience.

      03/30/2021

        The staff were enthusiastic and proactive in communicating with me and solving many technical problems in a timely manner.

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