Recombinant Human MLLT1(1-150 aa)(YEATS DOMAIN, Y78A) fused with GST tag at N-terminal was expressed in E. coli.
The ENL protein is part of the super elongation complex regulating RNA Pol II transcription. A chromosomal translocation resulting in an MLL-ENL fusion is involved in pediatric Acute Lymphoblastic Leukemia. ENL YEATS Domain, Y78A, Recombinant Human contains a substitution of alanine for tyrosine at position 78.
Recombinant GST-tagged protein at 1 mg/ml in 50 mM HEPES pH 7.3, 200 mM NaCl, 1 mM DTT, 10% glycerol.
ENL YEATS Domain, Y78A, Recombinant Human is useful for protein binding and screening experiments examining acetylated protein substrates.
Stable for six months at -80 centigrade from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.