Recombinant Human PRG4 protein, His-tagged
Cat.No. : | PRG4-361H |
Product Overview : | Recombinant Human PRG4(Val1151~Gly1241) fused with His tag at N-terminal was expressed in E. coli. |
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Description : | The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
Molecular Mass : | 11.6kDa |
AA Sequence : | MGHHHHHHSG S-VDGLTTLRNG TLVAFRGHYF WMLSPFSPPS PARRITEVWG IPSPIDTVFT RCNCEGKTFF FKDSQYWRFT NDIKDAGYPK PIFKGFGGLT G |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | PRG4 proteoglycan 4 [ Homo sapiens ] |
Official Symbol : | PRG4 |
Synonyms : | PRG4; proteoglycan 4; CACP, proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome); articular superficial zone protein; bG174L6.2; bG174L6.2 (MSF: megakaryocyte stimulating factor ); camptodactyly; arthropathy; coxa vara; pericarditis syndrome; FLJ32635; HAPO; Jacobs camptodactyly arthropathy pericarditis syndrome; JCAP; lubricin; megakaryocyte stimulating factor; MSF; SZP; superficial zone proteoglycan; megakaryocyte-stimulating factor; CACP; |
Gene ID : | 10216 |
mRNA Refseq : | NM_001127708 |
Protein Refseq : | NP_001121180 |
MIM : | 604283 |
UniProt ID : | Q92954 |
Chromosome Location : | 1q25-q31 |
Function : | polysaccharide binding; scavenger receptor activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionResearch is ongoing, but PRG4 is being investigated as a potential treatment for osteoarthritis due to its role in joint lubrication.
PRG4 provides lubrication to joints, reducing friction between cartilage surfaces and helping to maintain joint health and function.
It may have the potential to slow down joint degeneration by improving joint lubrication, but more research is needed to confirm its preventive effects.
PRG4 protein has several clinical applications, particularly in the field of orthopedics and rheumatology.
Yes, there are clinical trials exploring the use of PRG4 in the treatment of joint-related disorders.
Customer Reviews (3)
Write a reviewWith the PRG4 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.
the PRG4 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.
Its versatility and reliability make it a great asset in the pursuit of scientific discoveries.
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