"SIRPA" Related Products

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Recombinant Human SIRPA protein, Fc-tagged

Cat.No.: SIRPA-807H
Product Overview: Recombinant Human SIRPA(Glu 31 - Arg 370) fused with mouse IgG1 Fc tag at the C-terminus was expressed in HEK293.
Source: HEK293
Species: Human
Tag: Fc
Predicted N Terminal: Glu 31
Form: Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: Has a calculated MW of 63.5 kDa. The reducing (R) protein migrates as 70-105 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of protein by the LAL method.
Purity: >95% as determined by SDS-PAGE.>95% as determined by SEC-HPLC.
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4 centigrade); After reconstitution under sterile conditions for 3 months (-70 centigrade).
Gene Name: SIRPA signal-regulatory protein alpha [ Homo sapiens ]
Official Symbol: SIRPA
Synonyms: SIRPA; signal-regulatory protein alpha; protein tyrosine phosphatase, non receptor type substrate 1 , PTPNS1; tyrosine-protein phosphatase non-receptor type substrate 1; BIT; CD172a; MFR; MYD 1; P84; SHPS 1; SHPS1; SIRP; SIRP ALPHA 1; SIRPalpha; SIRPalpha2; myd-1 antigen; inhibitory receptor SHPS-1; macrophage fusion receptor; CD172 antigen-like family member A; tyrosine phosphatase SHP substrate 1; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; MYD-1; CD172A; PTPNS1;
Gene ID: 140885
mRNA Refseq: NM_001040022
Protein Refseq: NP_001035111
MIM: 602461
UniProt ID: P78324
Chromosome Location: 20p13
Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Hemostasis, organism-specific biosystem; IL-1 Signaling Pathway, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem; Signal regulatory protein (SIRP) family interactions, organism-specific biosystem;
Function: SH3 domain binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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