Recombinant Human SNRPA(8-278 aa) fused with His tag at N-terminal was expressed in E. coli.
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation.
PNHTIYINNL NEKIKKDELK KSLYAIFSQF GQILDILVSR SLKMRGQAFV IFKEVSSATN ALRSMQGFPF YDKPMRIQYA KTDSDIIAKM KGTFVERDRK REKRKPKSQE TPATKKAVQG GGATPVVGAV QGPVPGMPPM TQAPRIMHHM PGQPPYMPPP GMIPPPGLAP GQIPPGAMPP QQLMPGQMPP AQPLSENPPN HILFLTNLPE ETNELMLSML FNQFPGFKEV RLVPGRHDIA FVEFDNEVQA GAARD
Greater than 90% as determined by SDS-PAGE.
Store at -20 centigrade, for extended storage, conserve at -20 centigrade or -80 centigrade.