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Home > Products > Recombinant Proteins > Recombinant Mouse Tnfsf4 protein, Fc-tagged

Recombinant Mouse Tnfsf4 protein, Fc-tagged

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Fc(3)
Fc-His(1)
Flag(3)
His(3)
Human(3)
N/A(1)
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Cat.No.:
Tnfsf4-20M
Product Overview:
Recombinant Mouse Tnfsf4(Gln 49 - Leu 198) fused with human IgG1 Fc tag at the N-terminus was expressed in HEK293.
Description:
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
Source:
HEK293
Species:
Mouse
Tag :
Fc
Form:
Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Trehalose are added as protectants before lyophilization.
Molecular Mass:
Has a calculated MW of 44.5 kDa. The reducing (R) protein migrates as 47-55 kDa in SDS-PAGE due to glycosylation.
Protein length:
Gln 49 - Leu 198
Endotoxin:
Less than 1.0 EU per μg by the LAL method.
Purity:
>95% as determined by SDS-PAGE.
Storage:
Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4 centigrade); After reconstitution under sterile conditions for 3 months (-70 centigrade).


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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