Recombinant Rat NF1 Protein
Cat.No. : | NF1-3967R |
Product Overview : | Recombinant Rat NF1 full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Rat |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC. |
Storage Buffer : | PBS buffer |
Gene Name : | Nf1 neurofibromin 1 [ Rattus norvegicus ] |
Official Symbol : | NF1 |
Gene ID : | 24592 |
mRNA Refseq : | NM_012609.1 |
Protein Refseq : | NP_036741.1 |
MIM : | |
UniProt ID : | P97526 |
Products Types
◆ Recombinant Protein | ||
NF1-334H | Recombinant Human NF1 Protein, His-tagged | +Inquiry |
NF1-3625R | Recombinant Rat NF1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NF1-32H | Active Recombinant Human NF1 Protein (1197-1528), N-His tagged | +Inquiry |
NF1-335H | Recombinant Human NF1, GST-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionThe NF1 gene encodes neurofibromin, a protein primarily known for its role as a tumor suppressor. It regulates cell growth and differentiation.
Mutations in the NF1 gene can lead to a loss of neurofibromin function, resulting in uncontrolled RAS activation and increased cell proliferation, contributing to tumorigenesis.
Neurofibromin, the product of the NF1 gene, acts as a GTPase-activating protein (GAP) for RAS, accelerating the conversion of active RAS-GTP to its inactive form RAS-GDP, thereby negatively regulating the RAS/MAPK pathway.
NF1 interacts with several proteins in cellular pathways, including c-Raf, mTOR, and adenylate cyclase. Its dysregulation can influence the activity of these proteins and associated pathways.
By regulating the RAS/MAPK pathway, NF1 plays a crucial role in controlling cell growth, differentiation, and apoptosis.
Current therapeutic strategies for NF1-related disorders include surgical removal of tumors, targeted therapies like MEK inhibitors for plexiform neurofibromas, and regular monitoring for associated complications.
Neurofibromatosis Type 1 is characterized by multiple café-au-lait spots, skinfold freckling, neurofibromas, optic pathway gliomas, and certain bone abnormalities, among other manifestations.
Customer Reviews (3)
Write a reviewClear instructions, easy protocol.
Packaging was secure, intact.
Product arrived in good condition.
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