SRE Reporter Kit (MAPK/ERK Signaling Pathway )
| Cat.No. : | Kit-1869 |
| Product Overview : | The MAPK/ERK signaling pathway is a major participant in the regulation of cell growth and differentiation. It can be activated by various extracellular stimuli including mitogens, growth factors, and cytokines. Upon stimulation, MEK1/2 phosphorylate and activate ERK1/2. The activated ERK translocates to the nucleus where it phosphorylates and activates transcription factors. The TCFs (Ternary Complex Factors), including Elk1, are among the best-characterized transcription factor substrates of ERK. When phosphorylated by ERK, Elk1 forms a complex with Serum Response Factor (SRF) and binds to Serum Response Element (SRE), resulting in the expression of numerous mitogen-inducible genes. |
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| Size : | 500 reactions |
| Applications : | Monitor MAPK/ERK signaling pathway activity and SRF-mediated activity.Screen for activators or inhibitors of the MAPK/ERK signaling pathway.Study effects of RNAi or gene overexpression on the activity of the MAPK/ERK pathway. |
| Storage : | Stable at least 12 months from date of receipt, when stored as directed (-20°C) |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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