| Species : |
Human |
| Appearance : |
Powder mixture |
| Particle size : |
2 μm |
| Source : |
HEK293 |
| Bio-activity : |
Immobilized 48.8μg Biotinylated Human uPAR protein to 1mg Beads can bind the Anti-uPAR Antibody with an EC50 0.52 μg/mL. |
| Coupled amount of protein : |
≈1371pmol(48μg) uPAR protein/mg beads |
| Capacity : |
>277pmol (20μg) Anti-uPAR Ab/mg beads |
| Formulation : |
PBS, pH7.4, with 10% Trehalose |
| Reconstitution : |
2 mL sterile deionized water (1 mg beads/mL) |
| Background : |
Tumors are the result of uncontrolled proliferation of cells in different organs. Tumor development is a multistage process, that includes the generation of primary tumors, separation of tumors from primary sites, degradation of extracellular matrix (ECM), and distant metastasis of tumors. A variety of genes play important roles in the development of tumors, including the cell surface receptor urokinase-type plasminogen activator receptor (uPAR). uPAR is highly expressed in a variety of tumor cells, and a variety of signals regulated by uPAR play significant roles in tumor cell proliferation and metastasis, tumor-related glycolysis, the tumor microenvironment and angiogenesis. Studies have found that some specific drugs and antibodies have unique inhibitory effects on uPAR. |
| Application : |
This product is intended for immunocapture, biopanning and flow cytometry. This product is produced non-sterile. |
| Storage : |
Upon receipt, please store the Beads at -20°C for 1 year in lyophilized state. |
