Active Recombinant Full Length Human AURKC Protein, GST-tagged

• Cat.No.: AURKC-1853HF
• Product Overview: Full-length human AurC [1-275(end) amino acids of accession number NP_003151.2] was expressed as N-terminal GST-fusion protein (59 kDa) using baculovirus expression system. GST-AurC was purified by using glutathione sepharose chromatography.

Specification

• Source: Insect (sf21)
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCl, 150 mM NaCl, 0.1% CHAPS, 1 mM DTT, 10% glycerol, pH 7.5
• Bio-activity: The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorecence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip™3000.
• Protein length: 1-275(end)
• Purity: 80%
• Applications: SDS-PAGE
• Storage: Store at -80C. Avoid repeating freeze-thaws.

Gene Information

• Gene Name: aurora kinase C
• Official Symbol: AURKC
• Synonyms: AURKC;AIE2;AIK3;ARK3;AurC;HEL-S-90;SPGF5;STK13;aurora-C
• Protein Refseq: NP_003151.2
• UniProt ID: Q9UQB9

Reviews

06/01/2020

It is very stable and can be stored and used for a long time.

12/02/2019

This price is very reasonable and good value for money.

03/18/2019

The activity is very strong and can meet my research needs.

Q&As

What is the role of AURKC protein in germ cell genesis?

AURKC protein plays an important role in germ cell genesis and is involved in the development, maturation and fertilization of sperm and egg.

What is the regulatory mechanism of AURKC protein activity?

The activity of AURKC protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.

At what stage of cell mitosis does AURKC protein reach its peak expression?

It reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.

How is AURKC protein associated with cancer?

The abnormal expression of AURKC protein in some cancers is associated with the initiation and progression of tumors. Further studies on the mechanism of action of AURKC protein in cancer may contribute to the development of cancer therapy.

What is the cellular localization of AURKC protein?

AURKC protein is mainly localized in the nucleus and cytoplasm and participates in the regulation of cell mitosis.

How is AURKC protein associated with reproductive disorders and infertility?

Mutation or abnormal expression of AURKC protein is associated with reproductive disorders and infertility in both males and females. Studies have found that AURKC gene mutations may lead to abnormal sperm or egg development and dysfunction.