Active Recombinant Full Length Human ELAVL1 Protein, C-Flag-tagged

• Cat.No.: ELAVL1-75HFL
• Product Overview: Recombinant Full Length Human ELAVL1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: EMSA reaction positive control
• Molecular Mass: 35.9 kDa
• AA Sequence: MSNGYEDHMAEDCRGDIGRTNLIVN YLPQNMTQDELRSLFSSIGEVESAK LIRDKVAGHSLGYGFVNYVT AKDAERAINTLNGLRLQSKTIKVSY ARPSSEVIKDANLYISGLPRTMTQK DVEDMFSRFGRIINSRVLVD QTTGLSRGVAFIRFDKRSEAEEAIT SFNGHKPPGSSEPITVKFAANPNQN KNVALLSQLYHSPARRFGGP VHHQAQRFRFSPMGVDHMSGLSGVN VPGNASSGWCIFIYNLGQDADEGIL WQMFGPFGAVTNVKVIRDFN
  TNKCKGFGFVTMTNYEEAAMAIASL NGYRLGDKILQVSFKTNKSHKTRTR PLEQKLISEEDLAANDILDYKDDDD KV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

Gene Information

• Gene Name: ELAVL1 ELAV like RNA binding protein 1 [ Homo sapiens (human) ]
• Official Symbol: ELAVL1
• Synonyms: HUR; Hua; MelG; ELAV1
• Gene ID: 1994
• mRNA Refseq: NM_001419.3
• Protein Refseq: NP_001410.2
• MIM: 603466
• UniProt ID: Q15717

Reviews

12/19/2022

It is very pure and can be used with confidence.

07/20/2021

In enzymatic experiments, ELAVL1 was found to have high catalytic efficiency.

06/11/2020

In immunological experiments, it was found that ELAVL1 had good antigenicity and could induce target immune response.

Q&As

Is relationship between the ELAVL1 gene and the immune system?

Studies have shown that the ELAVL1 gene may be involved in the regulation of the immune system, especially in the inflammatory response.

What is the localization of the ELAVL1 gene in cells?

The protein encoded by the ELAVL1 gene is mainly located in the cytoplasm and nucleus.

What is the change in the expression level of ELAVL1 gene in tumors?

In some tumors, the expression level of ELAVL1 gene may be increased or decreased, which is related to the occurrence and progression of tumors.

What is the effect of ELAVL1 gene on apoptosis?

This gene may play an important role in the process of apoptosis, but its specific mechanism of action still needs further research.

How is the ELAVL1 gene involved in the differentiation of nerve cells?

ELAVL1 is involved in the differentiation of nerve cells by binding to and stabilizing neuronal cell-specific microRNAs.

In which tissues and organs is the ELAVL1 gene expressed?

This gene isexpressed in many tissues and organs, including the brain, heart, liver, muscles, etc.