| Description : |
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Bio-activity : |
ELISA capture for autoantibodies. |
| Molecular Mass : |
137.7 kDa |
| AA Sequence : |
MELAALCRWGLLLALLPPGAASTQV CTGTDMKLRLPASPETHLDMLRHLY QGCQVVQGNLELTYLPTNAS LSFLQDIQEVQGYVLIAHNQVRQVP LQRLRIVRGTQLFEDNYALAVLDNG DPLNNTTPVTGASPGGLREL QLRSLTEILKGGVLIQRNPQLCYQD TILWKDIFHKNNQLALTLIDTNRSR ACHPCSPMCKGSRCWGESSE DCQSLTRTVCAGGCARCKGPLPTDC CHEQCAAGCTGPKHSDCLACLHFNH SGICELHCPALVTYNTDTFE SMPNPEGRYTFGASCVTACPYNYLS TDVGSCTLVCPLHNQEVTAEDGTQR CEKCSKPCARVCYGLGMEHL REVRAVTSANIQEFAGCKKIFGSLA FLPESFDGDPASNTAPLQPEQLQVF ETLEEITGYLYISAWPDSLP DLSVFQNLQVIRGRILHNGAYSLTL QGLGISWLGLRSLRELGSGLALIHH NTHLCFVHTVPWDQLFRNPH QALLHTANRPEDECVGEGLACHQLC ARGHCWGPGPTQCVNCSQFLRGQEC VEECRVLQGLPREYVNARHC LPCHPECQPQNGSVTCFGLEADQCV ACAHYKDPPFCVARCPSGVKPDLSY MPIWKFPDEEGACQPCPINC THSCVDLDDKGCPAEQRASPLTSII SAVVGILLVVVLGVVFGILIKRRQQ KIRKYTMRRLLQETELVEPL TPSGAMPNQAQMRILKETELRKVKV LGSGAFGTVYKGIWIPDGENVKIPV AIKVLRENTSPKANKEILDE AYVMAGVGSPYVSRLLGICLTSTVQ LVTQLMPYGCLLDHVRENRGRLGSQ DLLNWCMQIAKGMSYLEDVR LVHRDLAARNVLVKSPNHVKITDFG LARLLDIDETEYHADGGKVPIKWMA LESILRRRFTHQSDVWSYGV TVWELMTFGAKPYDGIPAREIPDLL EKGERLPQPPICTIDVYMIMVKCWM IDSECRPRFRELVSEFSRMA RDPQRFVVIQNEDLGPASPLDSTFY RSLLEDDDMGDLVDAEEYLVPQQGF FCPDPAPGAGGMVHHRHRSS STRSGGGDLTLGLEPSEEEAPRSPL APSEGAGSDVFDGDLGMGAAKGLQS LPTHDPSPLQRYSEDPTVPL PSETDGYVAPLTCSPQPEYVNQPDV RPQPPSPREGPLPAARPAGATLERP KTLSPGKNGVVKDVFAFGGA VENPEYLTPQGGAAPQPHPPPAFSP AFDNLYYWDQDPPERGAPPSTFKGT PTAENPEYLGLDVPVTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways : |
Adherens junction, Bladder cancer, Calcium signaling pathway, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer |
