Active Recombinant Full Length Human OLR1 Protein, C-Flag-tagged

• Cat.No.: OLR1-693HFL
• Product Overview: Recombinant Full Length Human OLR1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Binding assay
• Molecular Mass: 30.8 kDa
• AA Sequence: MTFDDLKIQTVKDQPDEKSNGKKAK GLQFLYSPWWCLAAATLGVLCLGLV VTIMVLGMQLSQVSDLLTQE QANLTHQKKKLEGQISARQQAEEAS QESENELKEMIETLARKLNEKSKEQ MELHHQNLNLQETLKRVANC SAPCPQDWIWHGENCYLFSSGSFNW EKSQEKCLSLDAKLLKINSTADLDF IQQAISYSSFPFWMGLSRRN
  PSYPWLWEDGSPLMPHLFRVRGAVS QTYPSGTCAYIQRGAVYAENCILAA FSICQKKANLRAQTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: PPAR signaling pathway

Gene Information

• Gene Name: OLR1 oxidized low density lipoprotein receptor 1 [ Homo sapiens (human) ]
• Official Symbol: OLR1
• Synonyms: LOX1; LOXIN; SLOX1; CLEC8A; SCARE1
• Gene ID: 4973
• mRNA Refseq: NM_002543.4
• Protein Refseq: NP_002534.1
• MIM: 602601
• UniProt ID: P78380