Active Recombinant Full Length Human PIK3CG Protein, C-Flag-tagged

• Cat.No.: PIK3CG-210HFL
• Product Overview: Recombinant Full Length Human PIK3CG Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Surface Plasmon Ressonance (SPR)
• Molecular Mass: 126.3 kDa
• AA Sequence: MELENYKQPVVLREDNCRRRRRMKP RSAAASLSSMELIPIEFVLPTSQRK CKSPETALLHVAGHGNVEQM KAQVWLRALETSVAADFYHRLGPHH FLLLYQKKGQWYEIYDKYQVVQTLD CLRYWKATHRSPGQIHLVQR HPPSEESQAFQRQLTALIGYDVTDV SNVHDDELEFTRRGLVTPRMAEVAS RDPKLYAMHPWVTSKPLPEY LWKKIANNCIFIVIHRSTTSQTIKV SPDDTPGAILQSFFTKMAKKKSLMD IPESQSEQDFVLRVCGRDEY LVGETPIKNFQWVRHCLKNGEEIHV VLDTPPDPALDEVRKEEWPLVDDCT GVTGYHEQLTIHGKDHESVF TVSLWDCDRKFRVKIRGIDIPVLPR NTDLTVFVEANIQHGQQVLCQRRTS PKPFTEEVLWNVWLEFSIKI KDLPKGALLNLQIYCGKAPALSSKA SAESPSSESKGKVQLLYYVNLLLID HRFLLRRGEYVLHMWQISGK GEDQGSFNADKLTSATNPDKENSMS ISILLDNYCHPIALPKHQPTPDPEG DRVRAEMPNQLRKQLEAIIA TDPLNPLTAEDKELLWHFRYESLKH PKAYPKLFSSVKWGQQEIVAKTYQL LARREVWDQSALDVGLTMQL LDCNFSDENVRAIAVQKLESLEDDD VLHYLLQLVQAVKFEPYHDSALARF LLKRGLRNKRIGHFLFWFLR SEIAQSRHYQQRFAVILEAYLRGCG TAMLHDFTQQVQVIEMLQKVTLDIK SLSAEKYDVSSQVISQLKQK LENLQNSQLPESFRVPYDPGLKAGA LAIEKCKVMASKKKPLWLEFKCADP TALSNETIGIIFKHGDDLRQ DMLILQILRIMESIWETESLDLCLL PYGCISTGDKIGMIEIVKDATTIAK IQQSTVGNTGAFKDEVLNHW LKEKSPTEEKFQAAVERFVYSCAGY CVATFVLGIGDRHNDNIMITETGNL FHIDFGHILGNYKSFLGINK ERVPFVLTPDFLFVMGTSGKKTSPH FQKFQDICVKAYLALRHHTNLLIIL FSMMLMTGMPQLTSKEDIEY
  IRDALTVGKNEEDAKKYFLDQIEVC RDKGWTVQFNWFLHLVLGIKQGEKH SATRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS
• Protein Pathways: Acute myeloid leukemia, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Glioma, Inositol phosphate metabolism, Insulin signaling pathway, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Melanoma, mTOR signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Phosphatidylinositol signaling system, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, VEGF signaling pathway

Gene Information

• Gene Name: PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [ Homo sapiens (human) ]
• Official Symbol: PIK3CG
• Synonyms: PI3K; PIK3; IMD97; PI3CG; PI3Kgamma; p110gamma; p120-PI3K
• Gene ID: 5294
• mRNA Refseq: NM_002649.3
• Protein Refseq: NP_002640.2
• MIM: 601232
• UniProt ID: P48736