Active Recombinant Full Length Human RRM2 Protein, C-Flag-tagged

• Cat.No.: RRM2-137HFL
• Product Overview: Recombinant Full Length Human RRM2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Binding assay
• Molecular Mass: 44.7 kDa
• AA Sequence: MLSLRVPLAPITDPQQLQLSPLKGL SLVDKENTPPALSGTRVLASKTARR IFQEPTEPKTKAAAPGVEDE PLLRENPRRFVIFPIEYHDIWQMYK KAEASFWTAEEVDLSKDIQHWESLK PEERYFISHVLAFFAASDGI VNENLVERFSQEVQITEARCFYGFQ IAMENIHSEMYSLLIDTYIKDPKER EFLFNAIETMPCVKKKADWA LRWIGDKEATYGERVVAFAAVEGIF FSGSFASIFWLKKRGLMPGLTFSNE LISRDEGLHCDFACLMFKHL VHKPSEERVREIIINAVRIEQEFLT EALPVKLIGMNCTLMKQYIEFVADR LMLELGFSKVFRVENPFDFM
  ENISLEGKTNFFEKRVGEYQRMGVM SSPTENSFTLDADFTRTRPLEQKLI SEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Glutathione metabolism, Metabolic pathways, p53 signaling pathway, Purine metabolism, Pyrimidine metabolism

Gene Information

• Gene Name: RRM2 ribonucleotide reductase regulatory subunit M2 [ Homo sapiens (human) ]
• Official Symbol: RRM2
• Synonyms: R2; RR2; RR2M; C2orf48
• Gene ID: 6241
• mRNA Refseq: NM_001034.4
• Protein Refseq: NP_001025.1
• MIM: 180390
• UniProt ID: P31350

Reviews

05/14/2022

The professional gave me a detailed description of the RRM2 protein so that I could understand its biochemical properties.

03/31/2021

Smooth communication and timely shipment, allowing my experiment to be implemented as soon as possible.

11/20/2020

Cheap price, high quality products, worth buying again!

Q&As

What diseases has RRM2 been associated with the study of?

RRM2 has been associated with studies of liver, lung, and breast cancers.

How is RRM2 related to tumor development?

Elevated expression of RRM2 in some malignant tumors promotes tumor cell proliferation and immune escape, leading to malignant tumor progression.

What is the function of RRM2?

RRM2, which catalyzes the formation of deoxyribonucleotides from ribonucleotides, is involved in processes such as DNA repair and the cell cycle.

What is the relationship between RRM2 and ANXA1?

RRM2 interacts with ANXA1.

What is the relationship between RRM2 and RRM2B?

Both RRM2 and RRM2B are two small subunits of RR.