Active Recombinant Full Length Human TBX21 Protein, C-Flag-tagged

• Cat.No.: TBX21-125HFL
• Product Overview: Recombinant Full Length Human TBX21 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Enzyme substrate
• Molecular Mass: 58.1 kDa
• AA Sequence: MGIVEPGCGDMLTGTEPMPGSDEGR APGADPQHRYFYPEPGAQDADERRG GGSLGSPYPGGALVPAPPSR FLGAYAYPPRPQAAGFPGAGESFPP PADAEGYQPGEGYAAPDPRAGLYPG PREDYALPAGLEVSGKLRVA LNNHLLWSKFNQHQTEMIITKQGRR MFPFLSFTVAGLEPTSHYRMFVDVV LVDQHHWRYQSGKWVQCGKA EGSMPGNRLYVHPDSPNTGAHWMRQ EVSFGKLKLTNNKGASNNVTQMIVL QSLHKYQPRLHIVEVNDGEP EAACNASNTHIFTFQETQFIAVTAY QNAEITQLKIDNNPFAKGFRENFES MYTSVDTSIPSPPGPNCQFL GGDHYSPLLPNQYPVPSRFYPDLPG QAKDVVPQAYWLGAPRDHSYEAEFR AVSMKPAFLPSAPGPTMSYY RGQEVLAPGAGWPVAPQYPPKMGPA SWFRPMRTLPMEPGPGGSEGRGPED QGPPLVWTEIAPIRPESSDS
  GLGEGDSKRRRVSPYPSSGDSSSPA GAPSPFDKEAEGQFYNYFPNTRTRP LEQKLISEEDLAANDILDYKDDDDK V
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors

Gene Information

• Gene Name: TBX21 T-box transcription factor 21 [ Homo sapiens (human) ]
• Official Symbol: TBX21
• Synonyms: TBET; IMD88; T-PET; T-bet; TBLYM
• Gene ID: 30009
• mRNA Refseq: NM_013351.2
• Protein Refseq: NP_037483.1
• MIM: 604895
• UniProt ID: Q9UL17