Active Recombinant Human ACP1

• Cat.No.: ACP1-1068H
• Product Overview: Human ACP1 (NP_009030, 1 a.a.-158 a.a.) full-length recombinant protein with His tag expressed in Escherichia coli.

Specification

• Cat. No.: ACP1-1068H
• Description: The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes.
• Sequence: MGSSHHHHHH SSGLVPRGSH MAEQATKSVL FVCLGNICRS PIAEAVFRKL VTDQNISENW VIDSGAVSDW NVGRSPDPRA VSCLRNHGIH TAHKARQITK EDFATFDYIL CMDESNLRDL NRKSNQVKTC KAKIELLGSY DPQKQLIIED PYYGNDSDFE TVYQQCVRCC RAFLEKAH
• Theoretical MW (kDa): 20.1
• Form: Liquid
• Preparation Method: E. coli expression system
• Purity: > 95% by SDS-PAGE
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Activity: Activity tested: > 60,000 unit/mg of protein
• Application: SDS-PAGE
• Storage Buffer: In 20 mM MES 6.0, 0.1 mM PMSF, 2 mM EDTA (10% glycerol)
• Storage: Store at 4°C for 1-2 weeks. For long term storage store at -20°C or -80°C. Aliquot to avoid repeated freezing and thawing.
• Unitprot ID: P24666

Gene Information

• Gene Name: ACP1 acid phosphatase 1, soluble [ Homo sapiens ]
• Official Symbol: ACP1
• Synonyms: HAAP; MGC3499; MGC111030; low molecular weight phosphotyrosine protein phosphatase; LMW-PTP; LMW-PTPase; OTTHUMP00000109538; OTTHUMP00000109539; OTTHUMP00000199909; OTTHUMP00000199910; OTTHUMP00000199911; OTTHUMP00000199914; adipocyte acid phosphatase; red cell acid phosphatase 1; protein tyrosine phosphatase; acid phosphatase of erythrocyte; cytoplasmic phosphotyrosyl protein phosphatase; low molecular weight cytosolic acid phosphatase
• Gene ID: 52
• mRNA Refseq: NM_007099
• Protein Refseq: NP_009030
• MIM: 171500
• Chromosome Location: 2p25
• Pathway: Adherens junction; adherens junction; EPHA2 forward signaling; PDGFR-beta signaling pathway; riboflavin metabolism; riboflavin metabolism
• Function: Acid phosphatase activity; hydrolase activity; identical protein binding

Reviews

02/17/2023

The answers are very concise.

02/16/2023

There are all the questions I want to know.

02/16/2023

The answer was very patient.

Q&As

What are the two subtypes of ACP1?

F and S.

How to analyze ACP1 polymorphism?

Through the polymerase chain reaction-resreiction fragment length polymorphism.

What disease would be influenced by ABHD14A?

Esophageal cancer, gastric cancer and gastrointestinal cancer will lead to up-regulation of ACP1 expression, while colorectal cancer will reduce it.

Why is the blood glucose level of inactive ACP1 A low?

Because ACP1 has low dephosphorylation effect on insulin receptor.

How ACP1 works on respiration and cell oxidation?

To adjust the level of FMN and flavin adenine dinucleotide.

How to detect the protein level of ACP1?

Immunohistochemical staining observation of two related protein sections.

How many codominant alleles are there in ACP1?

Three.

What activities may ACP1 participate in the brain?

The cholesterol biosynthesis, neutotransmitter synthesis and it links to behavioral and cellular response to stress via p190RhoGAP

What's the ACP1 blocking buffer？

The PBS conraining 10% goat serum.

What protein is significantly associated with ACP1 in the brain?

The TPH2, DDC and GAD1.