Active Recombinant Human AGER protein, hFc&His-tagged

• Cat.No.: AGER-2676H
• Product Overview: Active Recombinant Human AGER/RAGE Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln24-Ala344) of human AGER/RAGE (Accession #NP_001127.1) fused with an Fc, 6×His tag at the C-terminus.

Specification

• Source: HEK293
• Species: Human
• Tag: hFc&His
• Form: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
• Bio-activity: 1.Measured by its binding ability in a functional ELISA. Immobilized Recombinant human HMGB1 at 2 μg/mL (100 μL/well) can bind Recombinant human AGER with a linear range of 15-50 ng/mL.
  2.Measured by its binding ability in a functional ELISA. Immobilized Human S100A12 at 2 μg/mL (100 μL/well) can bind recombinant Human AGER/RAGE, the EC50 of Human AGER/RAGE is 27.25 ng/mL.
• Molecular Mass: 100 kDa
• Protein Length: Gln24-Ala344
• Endotoxin: < 0.1 EU/μg of the protein by LAL method.
• Purity: > 90% by SDS-PAGE.
• Storage: Store the lyophilized protein at -20°C to -80 °C for long term.
  After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
• Reconstitution: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

Gene Information

• Gene Name: AGER advanced glycosylation end product-specific receptor [ Homo sapiens ]
• Official Symbol: AGER
• Synonyms: AGER; advanced glycosylation end product-specific receptor; RAGE; RAGE isoform sRAGE-delta; RAGE isoform NtRAGE-delta
• Gene ID: 177
• mRNA Refseq: NM_001136
• Protein Refseq: NP_001127
• MIM: 600214
• UniProt ID: Q15109

Reviews

02/26/2022

It's quality was evident in consistent results across replicates.

08/13/2021

 Protein consistently upregulated the expression of tissue-specific markers.

01/20/2020

 Gel electrophoresis bands displayed distinct separation, showcasing the product’s purity.

06/22/2019

It’s consistent outcomes supported reliable statistical analysis.

01/11/2017

Consistency and Compatibility Consistency in the product’s performance bolstered the credibility of our research findings.

Q&As

How does AGER affect bone health?

AGER is involved in bone metabolism and might influence osteoporosis and bone diseases.

Are there diagnostic applications for AGER?

AGER levels might serve as biomarkers for certain diseases, including diabetes.

How does AGER interact with AGEs?

AGER binds AGEs, initiating signaling cascades linked to inflammation, oxidative stress, and tissue damage.

How is AGER implicated in skin aging?

AGER contributes to skin aging through oxidative stress and collagen damage.

What is the AGER protein?

AGER stands for "Advanced Glycosylation End-Product Specific Receptor," a cell surface receptor.

Can the AGER protein impact inflammation?

Yes, AGER activation contributes to inflammation and immune responses.

How does AGER impact wound healing?

AGER activation can impair wound healing through inflammation and oxidative stress.

How does AGER influence neurodegenerative diseases?

AGER contributes to neuroinflammation and might play a role in neurodegeneration.

Can AGER influence kidney function?

AGER contributes to diabetic nephropathy and kidney dysfunction.

How does the AGER protein interact with AGEs?

AGER binds to AGEs, initiating cellular signaling pathways linked to inflammation and oxidative stress.

Can AGER influence lung health?

AGER is implicated in lung diseases and inflammation, such as chronic obstructive pulmonary disease.

Are there therapeutic strategies targeting AGER?

Researchers explore compounds that modulate AGER to mitigate its effects.

How is AGER involved in diabetic complications?

AGER contributes to diabetic complications by promoting inflammation and tissue damage.

How is the AGER protein involved in research?

AGER is studied for its implications in aging, diabetes, and various age-related diseases.

What is the function of the AGER protein?

AGER plays a role in mediating cellular responses to advanced glycation end products (AGEs).

Are there dietary interventions for AGER-related effects?

Consuming a low-AGE diet may help reduce AGER activation and its negative effects.

Can AGER impact immune responses?

AGER activation affects immune cell functions and influences immune responses.

Does AGER affect cardiovascular health?

AGER activation is linked to cardiovascular diseases, including atherosclerosis.

Are there other ligands for the AGER protein?

Yes, besides AGEs, AGER interacts with other ligands like HMGB1 and β-amyloid.

Is AGER research ongoing?

Yes, ongoing research aims to uncover new roles and therapeutic targets related to AGER.