Active Recombinant Human AGRN Protein, His-tagged
Cat.No. : | AGRN-875H |
Product Overview : | Recombinant Human AGRN (Accession # NP_940978) Ala1260-Pro2045, fused with an N-terminal 6-His tag, was produced in Chinese Hamster Ovary cell line, CHO-derived. |
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Source : | CHO Cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | His |
Form : | Lyophilized from a 0.2 µm filtered solution in PBS. |
Bio-activity : | Measured by the ability of the immobilized protein to support the adhesion of U-87 MG human glioblastoma/astrocytoma cells.The typical ED50 for this effect is 0.9 - 3.6 µg/mL after 1 hour incubation at 37 °C. Optimal dilutions should be determined by each laboratory for each application. |
Molecular Mass : | Recombinant Human AGRN, His-tagged has a calculated MW of 83.5 kDa. In SDS-PAGE migrates as 100-110 kDa, reducing conditions. |
Protein length : | Ala1260-Pro2045 |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Gene Name : | AGRN agrin [ Homo sapiens ] |
Official Symbol : | AGRN |
Synonyms : | AGRN; agrin; AGRIN; agrin proteoglycan; |
Gene ID : | 375790 |
mRNA Refseq : | NM_198576 |
Protein Refseq : | NP_940978 |
MIM : | 103320 |
UniProt ID : | O00468 |
Chromosome Location : | 1p36.33 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThe measurement of AGRN levels or its isoforms in biological fluids or tissues may hold potential as diagnostic markers for certain neurological disorders, although further research is needed.
AGRN interacts with specific receptors on the muscle and nerve cells, initiating a signaling cascade that leads to the clustering of acetylcholine receptors and the formation and maintenance of the NMJ.
Yes, AGRN has been shown to have roles outside of the NMJ, including in the development of the central nervous system, kidneys, and cardiovascular system.
AGRN exists in multiple isoforms generated by alternative splicing. The most well-known isoforms include the neural isoforms (Agrin-N) and the muscle-specific isoforms (Agrin-M).
AGRN consists of several functional domains, including N-terminal laminin G-like (LG) domains, central EGF-like repeats, a C-terminal domain, and a heparin-binding site.
AGRN has been found to promote tumor cell migration, invasion, and metastasis by interacting with receptors and signaling pathways that regulate cell adhesion, migration, and angiogenesis.
AGRN expression is tightly regulated during development and can be influenced by various signaling pathways, including Wnt, BMP, and Notch signaling.
AGRN interacts with two major receptors: muscle-specific kinase (MuSK) on the postsynaptic membrane and low-density lipoprotein receptor-related protein 4 (LRP4) on the presynaptic membrane.
AGRN plays a role in regulating synaptic plasticity by modulating the structure and function of synapses, including their strength and stability.
AGRN regulates the maturation and stabilization of synapses by promoting the clustering of postsynaptic receptors and facilitating the development of pre- and postsynaptic specializations.
Customer Reviews (5)
Write a reviewThe packaging was secure, and the proteins maintained their integrity and activity upon arrival.
I highly recommend their products for researchers seeking reliable reagents.
They offer excellent value for the price.
We rely on this protein for its consistent performance.
I am extremely satisfied with the prompt delivery of the proteins.
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