Active Recombinant Human AMBP
Cat.No. : | AMBP-230H |
Product Overview : | Recombinant Ulinastatin produced in Yeast is a single, glycosylated, polypeptide having 143 amino acids, molecular mass of 20 kDa and predicted pI of 4.5. |
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Description : | This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. |
Source : | Pichia Pastoris. |
Species : | Human |
Form : | Sterile Filtered solution. Formulated in 1X PBS. |
Bio-activity : | Greater than 3000U/mg as measured by BAEE method. |
Molecular Mass : | 20 kDa |
AA Sequence : | AVLPQEEEGS GGGQLVTEVT KKEDSCQLGY SAGPCMGMTS RYFYNGTSMACETFQYGGCM GNGNNFVTEK ECLQTCRTVA ACNLPIVRGP CRAFIQLWAFDAVKGKCVLF PYGGCQGNGN KFYSEKECRE YCGVPGDGDE ELL. |
Purity : | Greater than 98.0% as determined by RP-HPLC and FPLC. |
Storage : | Ulinastatin although stable at 15°C for 2 weeks, should be stored below -18°C. Please prevent freeze-thaw cycles. |
Publication : |
Mimicking filtration and transport of rotavirus and adenovirus in sand media using DNA-labeled, protein-coated silica nanoparticles. (2014)
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Gene Name : | AMBP alpha-1-microglobulin/bikunin precursor [ Homo sapiens (human) ] |
Official Symbol : | AMBP |
Synonyms : | AMBP; A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC; alpha-1-microglobulin/bikunin precursor; protein AMBP; bikunin; uristatin; protein HC; trypstatin; uronic-acid-rich protein; growth-inhibiting protein 19; inter-alpha-trypsin inhibitor light chain; complex-forming glycoprotein heterogeneous in charge |
Gene ID : | 259 |
mRNA Refseq : | NM_001633 |
Protein Refseq : | NP_001624 |
MIM : | 176870 |
UniProt ID : | P02760 |
Chromosome Location : | 9q32-q33 |
Pathway : | Binding and Uptake of Ligands by Scavenger Receptors; Scavenging of Heme from Plasma |
Function : | IgA binding; calcium channel inhibitor activity; calcium oxalate binding |
Products Types
◆ Recombinant Protein | ||
AMBP-302R | Recombinant Rat AMBP Protein, His (Fc)-Avi-tagged | +Inquiry |
AMBP-129C | Recombinant Cattle AMBP Protein, His-tagged | +Inquiry |
AMBP-128H | Recombinant Human AMBP Protein, His-tagged | +Inquiry |
AMBP-500M | Recombinant Mouse AMBP Protein, His (Fc)-Avi-tagged | +Inquiry |
AMBP-127H | Recombinant Human AMBP Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
AMBP-27H | Native Human AMBP | +Inquiry |
AMBP-5312H | Native Human Alpha-1-Microglobulin/Bikunin Precursor | +Inquiry |
◆ Lysates | ||
AMBP-001HCL | Recombinant Human AMBP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMBP expression levels and isoform variations can serve as diagnostic biomarkers for inflammatory diseases, immune dysregulation, or infection, aiding in disease diagnosis, monitoring, and prognostication.
AMBP expression is regulated by genetic and epigenetic factors, including transcription factors, DNA methylation, and histone modifications, which influence its expression patterns in different cell types and disease contexts.
AMBP modulates immune cell activities by regulating cellular adhesion, migration, phagocytosis, cytokine production, and immune cell differentiation through intracellular signaling pathways, such as MAPK and NF-魏B pathways.
AMBP participates in the regulation of complement activation by interacting with complement components, controlling the formation of membrane attack complexes and modulating the inflammatory response.
Targeting AMBP for therapeutic interventions in immune-mediated disorders or inflammatory conditions can be achieved through approaches such as small molecule inhibitors, antibody-based therapies, or gene editing techniques.
AMBP plays important roles in the immune system, including regulating inflammatory responses, modulating complement activation, and contributing to host defense mechanisms.
AMBP is released or secreted by immune cells through various mechanisms, including vesicular trafficking, exosomes, or proteolytic cleavage, which can be exploited for therapeutic purposes or biomarker discovery.
AMBP contributes to tissue homeostasis and immune surveillance in different organs, such as the kidney, lung, or reproductive system, and its dysregulation can have implications in tissue damage, autoimmune diseases, or infections in specific organ systems.
AMBP interacts with various immune-related proteins, such as complement components C3 and C5, cytokines, and cell surface receptors, influencing immune cell functions, immune signaling, and inflammation processes.
The structural features of AMBP, including its two domains (伪1-microglobulin and bikunin), are crucial for its immune-related functions, protein-protein interactions, and stability.
Customer Reviews (3)
Write a reviewCompatibility with various protein modification detection methods.
Enhanced data reproducibility in protein quantification.
Comprehensive profiling of protein expression patterns.
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