Active Recombinant Human ASAH2, His-tagged
Cat.No. : | ASAH2-284H |
Product Overview : | Recombinant Human ASAH2 (Accession # AAF86240) Thr15-Ile761, fused with an N-terminal 6-His tag, was produced in Chinese Hamster Ovary cell line, CHO-derived. |
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Source : | CHO cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | His |
Form : | Supplied as a 0.2 µm filtered solution in MES, NaCl and Sodium Cholate. |
Bio-activity : | Measured by its ability to hydrolyze the substrate C12:0 ceramide into sphingosine and dodecanoic acid. The specific activity is >5,000 pmol/min/µg, as measured under the described conditions. |
Molecular Mass : | Recombinant Human ASAH2, His-tagged has a calculated MW of 83 kDa. In SDS-PAGE migrates as 132 kDa, reducing conditions. |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Gene Name : | ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 [ Homo sapiens ] |
Official Symbol : | ASAH2 |
Synonyms : | ASAH2; N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2; neutral ceramidase; mitochondrial ceramidase; non-lysosomal ceramidase; acylsphingosine deacylase 2; neutral/alkaline ceramidase; N-acylsphingosine amidohydrolase 2; HNAC1; BCDase; LCDase; NCDase; N-CDase; |
Gene ID : | 56624 |
mRNA Refseq : | NM_001143974 |
Protein Refseq : | NP_001137446 |
MIM : | 611202 |
UniProt ID : | Q9NR71 |
Chromosome Location : | 10q11.23 |
Products Types
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ASAH2-251H | Recombinant Human ASAH2 Protein, His&hFc-tagged | +Inquiry |
ASAH2-3252R | Recombinant Rat ASAH2 protein, His-SUMO-tagged | +Inquiry |
◆ Lysates | ||
ASAH2-2806MCL | Recombinant Mouse ASAH2 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionPost-translational modifications, such as phosphorylation, may impact ASAH2 activity, although further research is needed for a comprehensive understanding.
While specific inhibitors for ASAH2 are not yet available, researchers are actively exploring potential compounds that can modulate its activity.
ASAH2 is primarily localized in the lysosomes, where it carries out the ceramide hydrolysis process.
Deficiency in ASAH2 activity can lead to the accumulation of ceramides, which may disrupt cellular signaling and contribute to disease development.
ASAH2 gene expression can be regulated by various factors, including transcription factors, epigenetic modifications, and signaling pathways.
Mutations in the ASAH2 gene have been associated with a rare form of hereditary sensory and autonomic neuropathy (HSAN) called HSAN1C.
Yes, ASAH2 is ubiquitously expressed in various tissues throughout the body.
Customer Reviews (3)
Write a reviewIt reliably and accurately detects and quantifies target molecules, allowing for precise measurement of analytes in my samples.
I highly recommend the ASAH2 Protein for its outstanding performance in ELISA assays.
The sensitivity and specificity of the ASAH2 Protein have consistently delivered robust and consistent results, enhancing the efficiency and accuracy of my experimental workflows.
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