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Active Recombinant Human ATP1B2 Protein, His-tagged

Cat.No. : ATP1B2-18H
Product Overview : Recombinant human ATP1B2 (68-290aa, 232aa), fused to His-tag at Cterminus, was expressed in insect cell and purified by using conventional chromatography techniques.
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Description : The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene.
Source : Insect cell
Species : Human
Tag : His
Form : Liquid
Bio-activity : Specific activity is > 3,000 pmol/min/μg, and is defined as the amount of enzyme that hydrolyze 1.0 pmole of Adenosine 5-triphosphate to phosphate per minute per minute at pH 7.5 at 25 centigrade.
Molecular Mass : 26.4 kDa
Protein length : 68-290
AA Sequence : DHTPKYQDRLATPGLMIRPKTENLD VIVNVSDTESWDQHVQKLNKFLEPY NDSIQAQKNDVCRPGRYYEQPDNGV LNYPKRACQFNRTQLGNCSGIGDST HYGYSTGQPCVFIKMNRVINFYAGA NQSMNVTCAGKRDEDAENLGNFVMF PANGNIDLMYFPYYGKKFHVNYTQP LVAVKFLNVTPNVEVNVECRINAAN IATDDERDKFAGRVAFKLRINKT
Endotoxin : < 1 EU/μg of protein (determined by LAL method)
Purity : > 90% by SDS-PAGE
Applications : SDS-PAGE, Enzyme Activity
Storage : Can be stored at 2 to 8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/mL (determined by absorbance at 280nm)
Storage Buffer : Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Gene Name : ATP1B2 ATPase Na+/K+ transporting subunit beta 2 [ Homo sapiens (human) ]
Official Symbol : ATP1B2
Synonyms : ATP1B2; ATPase Na+/K+ transporting subunit beta 2; AMOG; sodium/potassium-transporting ATPase subunit beta-2; ATPase, Na+/K+ transporting, beta 2 polypeptide; Na, K-ATPase beta-2 polypeptide; adhesion molecule in glia; adhesion molecule on glia; sodium pump subunit beta-2; sodium-potassium ATPase subunit beta 2 (non-catalytic); sodium/potassium-dependent ATPase beta-2 subunit; sodium/potassium-dependent ATPase subunit beta-2; sodium/potassium-transporting ATPase beta-2 chain; EC 7.2.2.13
Gene ID : 482
mRNA Refseq : NM_001678
Protein Refseq : NP_001669
MIM : 182331
UniProt ID : P14415

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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