Active Recombinant Human ATRN protein, His-tagged

• Cat.No.: ATRN-825H
• Product Overview: Recombinant Human ATRN(Ala84-Gln1272) fused with His tag at C-terminal was expressed in CHO.

Specification

• Source: CHO
• Species: Human
• Tag: His
• Predicted N Terminal: Ala84
• Form: Lyophilized from a 0.2 μm filtered solution in PBS.
• Bio-activity: Measured by its binding ability in a functional ELISA. When recombinant mouse Agouti is coated at 1 μg/mL, Recombinant Human Attractin binds with apparent KD <40 nM.
• Molecular Mass: Predicted Molecular Mass: 135 kDa;SDS-PAGE: 150-180 kDa, reducing conditions
• Endotoxin: <0.10 EU per 1 μg of the protein by the LAL method.
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Storage: Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Reconstitution: Reconstitute at 500 μg/mL in PBS.

Gene Information

• Gene Name: ATRN attractin [ Homo sapiens ]
• Official Symbol: ATRN
• Synonyms: ATRN; attractin; DPPT L; mahogany protein; MGCA; attractin-2; mahogany homolog; DPPT-L; KIAA0548; MGC126754
• Gene ID: 8455
• mRNA Refseq: NM_139322
• Protein Refseq: NP_647538
• MIM: 603130
• UniProt ID: O75882
• Chromosome Location: 20p13
• Function: binding; receptor activity; sugar binding

Reviews

11/13/2022

ATRN's exceptional purity ensures accurate and reproducible experimental results.

07/07/2022

The protein manufacturer's products are backed by strong scientific research and development to provide customers with cutting-edge solutions.

03/04/2022

Because ATRN is resistant to degradation and its stability under various experimental conditions makes it the best choice for Western blot analysis.

Q&As

What diseases or symptoms can be caused by ATRN mutations?

ATRN gene mutations may lead to hereditary hemorrhagic telangiectasia and other diseases. The main features of the disease include telangiectasia on the skin and mucosa, epistaxis, and bleeding in internal organs.

Are there other genes that interact with the ATRN gene?

Yes, the ATRN gene may interact with other genes involved in the regulation of cell development and function, such as the Netrin-1 gene in nervous system development. These interactions may affect the function and regulatory network of ATRN genes.

Is the ATRN gene regulated?

Yes, ATRN gene expression is affected by a variety of regulatory factors, including binding of transcription factors, activation of signaling pathways, etc. These regulatory mechanisms ensure the adaptability and stability of the ATRN gene.

Is ATRN gene associated with cancer?

At present, no direct association between ATRN gene and cancer has been found. However, the regulatory role of ATRN genes in cell proliferation and differentiation may be indirectly related to tumorigenesis and progression.

What is the expression pattern of ATRN gene?

The ATRN gene is widely expressed in the human body, but its expression level may vary in different tissues and organs. Its expression is higher in brain, retina, kidney and other tissues.

What progress has been made in the research of ATRN gene?

The research on ATRN gene mainly focuses on the analysis of its structure and function, the exploration of its regulatory mechanism, and the relationship with genetic diseases. So far, several important findings have been made regarding the function and regulation of ATRN genes.