Active Recombinant Human BIRC3 Protein, GST-tagged

• Cat.No.: BIRC3-635H
• Product Overview: Recombinant Human BIRC3 fused with GST tag at N-terminal was expressed in Insect cells.

Specification

• Description: BIRC3 or baculoviral IAP repeat containing 3 is a member of the IAP family of proteins. BIRC3 inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and thereby interfering with activation of ICE-like proteases. BIRC3 inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. BIRC3 is a potential oncogene which is overexpressed in multiple lung cancers with or without higher copy numbers. BIRC3 is a key regulator of NOD innate immunity signaling.
• Source: Insect cells
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol
• Bio-activity: 17 nmol/min/mg
• Molecular Mass: 105 kDa
• Purity: >75%
• Applications: Ubiquitin Enzyme Assay, Western Blot
• Stability: 1 year at - 70 centigrade from the date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 ug/ml

Gene Information

• Gene Name: BIRC3 baculoviral IAP repeat containing 3 [ Homo sapiens ]
• Official Symbol: BIRC3
• Synonyms: BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF49; TNFR2 TRAF signaling complex protein; IAP-1; IAP homolog C; RING finger protein 49; baculoviral IAP repeat-containing 3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1; AIP1; API2; CIAP2; HAIP1; HIAP1; c-IAP2
• Gene ID: 330
• mRNA Refseq: NM_001165
• Protein Refseq: NP_001156
• MIM: 601721
• UniProt ID: Q13489

Reviews

11/09/2019

Key to our research success, a trusted partner.

06/22/2017

Dependable partner, integral to research integrity.

06/12/2017

Efficient and precise, a research necessity.

Q&As

What is the primary role of BIRC3 in apoptosis regulation?

BIRC3 (cIAP2) inhibits apoptosis, regulating cell death.

How does BIRC3 interact with other proteins in apoptosis pathways?

BIRC3 interacts with proteins in apoptosis pathways, influencing cell survival.

What role does BIRC3 play in immune responses?

BIRC3 plays a role in immune response, especially in inflammation.

How do genetic variations in BIRC3 affect disease susceptibility?

Genetic changes in BIRC3 affect susceptibility to cancers and immune disorders.

How does BIRC3 contribute to cell survival?

It promotes cell survival by blocking apoptosis signals.

What is the impact of altered BIRC3 activity on inflammatory conditions?

Altered BIRC3 activity impacts inflammatory disease progression.

What potential therapeutic applications arise from targeting BIRC3 in inflammatory and cancerous diseases?

Targeting BIRC3 could treat diseases with abnormal apoptosis, like cancer and inflammation.