Active Recombinant Human BMP3 Protein

• Cat.No.: BMP3-012H
• Product Overview: The mature recombinant human BMP-3 protein consists of 110 amino acids (363-472) without tag was expressed in E. coli.

Specification

• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands.
• Source: E. coli
• Species: Human
• Bio-activity: Measured by its ability to inhibit BMP-2-induced activity in MC3T3-E1 mouse preosteoblast cells. 30 μg/mL of hBMP-3 will antagonize hBMP-2 (0.25 μg/mL) induction of alkaline phosphatase in MC3T3E1 cells by >50%.
• Molecular Mass: 12.5 kDa
• Product-Related Proteins: 363-472
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: BMP3 bone morphogenetic protein 3 [ Homo sapiens (human) ]
• Official Symbol: BMP3
• Synonyms: BMP3; bone morphogenetic protein 3; BMP-3A; bone morphogenetic protein 3; bone morphogenetic protein 3 (osteogenic); bone morphogenetic protein 3A; osteogenin
• Gene ID: 651
• mRNA Refseq: NM_001201
• Protein Refseq: NP_001192
• MIM: 112263
• UniProt ID: P12645