Active Recombinant Human CFHR4 Protein, His-tagged
| Cat.No. : | CFHR4-83H |
| Product Overview : | Recombinant human Complement Factor H-related 4/CFHR4 protein (Gln19-Glu331), with a C-terminal 10-His tag, expressed in Spodoptera frugiperda, Sf 21 (baculovirus). |
- Specification
- Gene Information
- Related Products
| Description : | This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene. |
| Source : | Insect cell |
| Species : | Human |
| Tag : | His |
| Bio-activity : | Measured by its binding ability in a functional ELISA. When Recombinant Mouse Complement Component C3d is immobilized at 2 μg/mL (100 μL/well), Recombinant Human Complement Factor H‑related 4/CFHR4 binds with an ED50 of 1-6 ng/mL. |
| Molecular Mass : | 37 kDa |
| Protein length : | 19-331 |
| Endotoxin : | < 0.10 EU/μg of the protein by the LAL method. |
| Purity : | > 95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
| Applications : | Bioactivity |
| Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, ≤ -20 centigrade under sterile conditions after reconstitution. |
| Storage Buffer : | Lyophilized from a 0.2 μm filtered solution in Tris and NaCl with Trehalose. |
| Reconstitution : | Reconstitute at 500 μg/mL in water. |
| Shipping : | The product is shipped at ambient temperature. |
| Gene Name : | CFHR4 complement factor H related 4 [ Homo sapiens (human) ] |
| Official Symbol : | CFHR4 |
| Synonyms : | CFHR4; complement factor H related 4; FHR4; CFHL4; FHR-4; complement factor H-related protein 4 |
| Gene ID : | 10877 |
| mRNA Refseq : | NM_006684 |
| Protein Refseq : | NP_006675 |
| MIM : | 605337 |
| UniProt ID : | Q92496 |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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