Active Recombinant human CLEC12B protein, Fc-tagged

• Cat.No.: CLEC12B-01H
• Product Overview: Recombinant human CLEC12B protein, Fc-tagged was expressed in CHO cell

Specification

• Description: Enables protein phosphatase binding activity and signaling receptor inhibitor activity. Involved in natural killer cell inhibitory signaling pathway; negative regulation of natural killer cell mediated cytotoxicity; and negative regulation of signaling receptor activity. Located in external side of plasma membrane. Part of protein-containing complex.
• Source: CHO
• Species: Human
• Tag: Fc
• Form: Disulfide-linked homodimer
• Bio-activity: Measured by its binding ability in a functional ELISA. When Recombinant Human CLEC12B Fc Chimera is immobilized at 4 µg/mL (100 µL/well), Recombinant Human MICA Fc Chimera binds with an ED50 of 1-6 μg/mL.
• Molecular Mass: 51 kDa
• N-terminal Sequence Analysis: Met
• Endotoxin: <0.10 EU per 1 μg of the protein by the LAL method.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Applications: Bioactivity
• Storage: 12 months from date of receipt, ≤ -20 °C as supplied.
  1 month, 2 to 8 °C under sterile conditions after reconstitution.
  3 months, ≤ -20 °C under sterile conditions after reconstitution.
• Reconstitution: Reconstitute at 500 μg/mL in PBS.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Gene Information

• Gene Name: CLEC12B C-type lectin domain family 12 member B [ Homo sapiens (human) ]
• Official Symbol: CLEC12B
• Synonyms: C-type lectin domain family 12 member B, C-type lectin domain family 12, member B, CLEC12B, Macrophage Antigen H, UNQ5782, UNQ5782/PRO16089
• Gene ID: 387837
• mRNA Refseq: NM_001129998.3
• Protein Refseq: NP_001123470.1
• MIM: 617573
• UniProt ID: Q2HXU8