Active Recombinant Human CNR1 Full Length Transmembrane protein, His-tagged
Cat.No. : | CNR1-718H |
Product Overview : | Recombinant Human CNR1 protein(P21554)(1-472aa), fused with C-terminal His tag, was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
- Download
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized Human CNR1 at 10 μg/mL can bind Anti-CNR1 recombinant antibody, the EC50 is 41.72-63.54 ng/mL. |
Molecular Mass : | 54.6 kDa |
Protein Length : | 1-472aa |
AA Sequence : | MKSILDGLADTTFRTITTDLLYVGS NDIQYEDIKGDMASKLGYFPQKFPL TSFRGSPFQEKMTAGDNPQLVPADQ VNITEFYNKSLSSFKENEENIQCGE NFMDIECFMVLNPSQQLAIAVLSLT LGTFTVLENLLVLCVILHSRSLRCR PSYHFIGSLAVADLLGSVIFVYSFI DFHVFHRKDSRNVFLFKLGGVTASF TASVGSLFLTAIDRYISIHRPLAYK RIVTRPKAVVAFCLMWTIAIVIAVL PLLGWNCEKLQSVCSDIFPHIDETY LMFWIGVTSVLLLFIVYAYMYILWK AHSHAVRMIQRGTQKSIIIHTSEDG KVQVTRPDQARMDIRLAKTLVLILV VLIICWGPLLAIMVYDVFGKMNKLI KTVFAFCSMLCLLNSTVNPIIYALR SKDLRHAFRSMFPSCEGTAQPLDNS MGDSDCLHKHANNAASVHRAAESCI KSTVKIAKVTMSVSTDTSAEAL |
Endotoxin : | Less than 1.0 EU/ug as determined by LAL method. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Reconstitution : | Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. |
Gene Name : | CNR1 cannabinoid receptor 1 (brain) [ Homo sapiens ] |
Official Symbol : | CNR1 |
Synonyms : | CNR1; cannabinoid receptor 1 (brain); CNR; cannabinoid receptor 1; CANN6; CB R; CB1; CB1A; CB1K5; central cannabinoid receptor; CB-R; CB1R; |
Gene ID : | 1268 |
mRNA Refseq : | NM_001160226 |
Protein Refseq : | NP_001153698 |
MIM : | 114610 |
UniProt ID : | P21554 |
Products Types
◆ Recombinant Protein | ||
CNR1-2711H | Recombinant Human CNR1 Protein, His-tagged | +Inquiry |
CNR1-772R | Recombinant Rhesus Macaque CNR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
CNR1-1498R | Recombinant Rat Cnr1 Protein | +Inquiry |
CNR1-1597H | Recombinant Human CNR1 Protein, GST-tagged | +Inquiry |
CNR1-3314C | Recombinant Chicken CNR1 | +Inquiry |
◆ Lysates | ||
CNR1-7395HCL | Recombinant Human CNR1 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1180 | CNR1 CHO-K1 β-Arrestin GPCR Assay Kit | +Inquiry |
Kit-1179 | cAMP CNR1 (CB1) CHO-K1 GPCR Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionThe protein receptor agonists can bind to receptors, activate receptors, and promote their signal transduction, resulting in physiological effects. CNR1 receptor antagonists, on the other hand, can bind to the receptor and prevent endocannabinoids from binding to the receptor, thereby inhibiting its signal transduction.
There are many types of mutations in the CNR1 gene, including single nucleotide substitution, insertion, or deletion. These mutations may cause structural and functional changes in the CNR1 receptor, affecting its binding and signal transduction to endocannabinoids.
CNR1 receptors play an important role in neuronal connections and neural circuits. It is involved in the growth, differentiation, and synapse formation of neurons, as well as in the regulation of neural circuits and signal transduction.
CNR1 receptors have potential applications in drug development. Some studies have shown that CNR1 receptor agonists or antagonists can be used to treat neurological disorders such as pain, depression, and anxiety.
Polymorphisms in the CNR1 gene may cause differences in individual responses to medications. Some polymorphisms may increase an individual's sensitivity or tolerance to medications, which can affect the efficacy and safety of medications.
For example, some drugs, toxins, or stressors may affect the expression level of the CNR1 gene, thus affecting its function and signal transduction processes.
Customer Reviews (3)
Write a reviewDNA binding ability is strong, and it performs well in related experiments.
The immunogenicity is very weak, does not cause an immune response, and has a high safety profile.
CNR1 has a long shelf life and good stability, which is convenient for the continuity of subsequent experiments.
Ask a Question for All CNR1 Products
Required fields are marked with *
My Review for All CNR1 Products
Required fields are marked with *
Inquiry Basket