Active Recombinant Human CXCR4 Full Length Transmembrane protein, His-tagged
Cat.No. : | CXCR4-1038H |
Product Overview : | Recombinant Human CXCR4 protein(P61073)(1-352aa), fused with C-terminal His tag, was expressed in HEK293. |
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Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized Human CXCR4 at 10 μg/mL can bind Anti-CXCR4 recombinant antibody, the EC50 is 101.7-253.6 ng/mL. |
Molecular Mass : | 41.5 kDa |
Protein Length : | 1-352aa |
AA Sequence : | MEGISIYTSDNYTEEMGSGDYDSMK EPCFREENANFNKIFLPTIYSIIFL TGIVGNGLVILVMGYQKKLRSMTDK YRLHLSVADLLFVITLPFWAVDAVA NWYFGNFLCKAVHVIYTVNLYSSVL ILAFISLDRYLAIVHATNSQRPRKL LAEKVVYVGVWIPALLLTIPDFIFA NVSEADDRYICDRFYPNDLWVVVFQ FQHIMVGLILPGIVILSCYCIIISK LSHSKGHQKRKALKTTVILILAFFA CWLPYYIGISIDSFILLEIIKQGCE FENTVHKWISITEALAFFHCCLNPI LYAFLGAKFKTSAQHALTSVSRGSS LKILSKGKRGGHSSVSTESESSSFH SS |
Endotoxin : | Less than 1.0 EU/ug as determined by LAL method. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Reconstitution : | Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. |
Gene Name : | CXCR4 chemokine (C-X-C motif) receptor 4 [ Homo sapiens ] |
Official Symbol : | CXCR4 |
Synonyms : | CXCR4; chemokine (C-X-C motif) receptor 4; chemokine (C X C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CD184; D2S201E; fusin; HM89; HSY3RR; LESTR; NPY3R; NPYR; NPYY3R; CXC-R4; CXCR-4; CD184 antigen; SDF-1 receptor; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; FB22; LAP3; LCR1; WHIM; NPYRL; |
Gene ID : | 7852 |
mRNA Refseq : | NM_001008540 |
Protein Refseq : | NP_001008540 |
MIM : | 162643 |
UniProt ID : | P61073 |
Products Types
◆ Recombinant Protein | ||
CXCR4-011H | Recombinant Human CXCR4 Protein, C-hFc tagged | +Inquiry |
CXCR4-2181H | Recombinant Human CXCR4 Protein, GST-tagged | +Inquiry |
CXCR4-2101M | Recombinant Mouse CXCR4 Protein, His (Fc)-Avi-tagged | +Inquiry |
CXCR4-186H | Recombinant Human CXCR4 Protein, Fc-tagged | +Inquiry |
CXCR4-1175H | Recombinant Human CXCR4 Protein, His-SUMO/MYC-tagged | +Inquiry |
◆ Lysates | ||
CXCR4-7161HCL | Recombinant Human CXCR4 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1199 | CXCR4 Total GPCR Internalization Assay Kit | +Inquiry |
Kit-1197 | cAMP CXCR4 CHO-K1 GPCR Assay Kit | +Inquiry |
Kit-1198 | cAMP CHO-K1 CXCR4 Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionCXCR4 participates in chemotaxis and migration of immune cells, facilitating their movement toward specific tissues during the immune response.
Specific chemokines or ligands, such as CXCL12, bind to CXCR4, influencing its role in immune cell activation and recruitment.
CXCR4 is predominantly localized on the cell surface of immune cells, particularly within the membrane of T cells and monocytes.
Dysregulation or abnormal expression of CXCR4 is associated with diseases such as cancer, HIV/AIDS, and autoimmune disorders, particularly affecting immune cell function.
There are potential therapeutic implications related to CXCR4 in diseases involving immune dysregulation and inflammation, making it a target for drug development.
CXCR4 contributes to the regulation of inflammatory responses and immune cell trafficking in various tissues, influencing the outcome of immune reactions.
C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in cellular processes, primarily contributing to immune responses and cell migration.
Customer Reviews (3)
Write a reviewThe responsive customer support team provided quick resolutions to any queries or issues we encountered.
The product's cost-effectiveness and clear instructions were instrumental in our experimental design.
We found the product's straightforward protocols highly conducive to seamless integration into our lab work.
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