Active Recombinant Human DHODH Protein, Met/His-tagged
Cat.No. : | DHODH-01H |
Product Overview : | Recombinant Human DHODH Protein (Thr31-Arg395) with N-terminal Met and 6-His tag was expressed in E. coli. |
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Description : | The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. |
Source : | E. coli |
Species : | Human |
Tag : | Met/His |
Bio-activity : | Measured by its reduction of 2,6-dichloroindophenol during the oxidation of dihydroorotate. The specific activity is >15000 pmol/min/μg, as measured under the described conditions. |
Molecular Mass : | 41 kDa |
N-terminal Sequence Analysis : | Met |
Endotoxin : | < 0.10 EU/μg of the protein by the LAL method. |
Purity : | > 95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Applications : | Enzyme Activity |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 centigrade as supplied. 3 months, -20 to -70 centigrade under sterile conditions after opening. |
Storage Buffer : | Supplied as a 0.2 μm filtered solution in Tris, NaCl and Glycerol. |
Shipping : | The product is shipped with polar packs. |
Gene Name : | DHODH dihydroorotate dehydrogenase (quinone) [ Homo sapiens (human) ] |
Official Symbol : | DHODH |
Synonyms : | DHODH; dihydroorotate dehydrogenase (quinone); URA1; POADS; DHOdehase; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate oxidase; human complement of yeast URA1; EC 1.3.5.2 |
Gene ID : | 1723 |
mRNA Refseq : | NM_001361 |
Protein Refseq : | NP_001352 |
MIM : | 126064 |
UniProt ID : | Q02127 |
Products Types
◆ Recombinant Protein | ||
DHODH-2590H | Recombinant Human DHODH Protein, GST-tagged | +Inquiry |
DHODH-1517R | Recombinant Rat DHODH Protein, His (Fc)-Avi-tagged | +Inquiry |
DHODH-2355M | Recombinant Mouse DHODH Protein, His (Fc)-Avi-tagged | +Inquiry |
Dhodh-2546M | Recombinant Mouse Dhodh Protein, Myc/DDK-tagged | +Inquiry |
DHODH-2541M | Recombinant Mouse DHODH Protein (31-395 aa), His-tagged | +Inquiry |
◆ Lysates | ||
DHODH-6944HCL | Recombinant Human DHODH 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIt catalyzes a key step in the pyrimidine biosynthesis pathway, converting dihydroorotate to orotate.
DHODH, dihydroorotate dehydrogenase, is crucial for the de novo synthesis of pyrimidines, essential for DNA and RNA synthesis.
DHODH collaborates with other enzymes in pyrimidine biosynthesis, playing a role in nucleotide metabolism.
DHODH is important for cell proliferation, as pyrimidine synthesis is essential for DNA replication and cell growth.
Genetic mutations in DHODH can disrupt nucleotide synthesis, affecting cellular replication and function.
Altered DHODH activity is linked with autoimmune conditions, as it affects lymphocyte proliferation and function.
Targeting DHODH in therapies could be effective in treating autoimmune diseases and certain cancers by modulating pyrimidine synthesis.
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