Active Recombinant Human Fc Receptor-Like 2, His-tagged
Cat.No. : | FCRL2-497H |
Product Overview : | Recombinant Human FCRL2is expressed in Murine myeloma cell line, which has a molecule weight of 41.9kDa. Leu20 Asp395, with a Cterminal 6His tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | FCRL2-497H |
Description : | Fc receptorlike 2 (FCRL2),also known as FcRH2 and IRTA4, belongs to the family of glycoprotein homologsof classical immunoglobulin (Ig) Fc receptors. In human, the type I transmembraneFCRL protein family contains from three to nine immunoglobulinlike domains. Maturehuman FcRH2 consists of a 382 amino acid (aa) extracellular domain (ECD) withfour Iglike C2set domains, a 21 aa transmembrane segment, and an 86 aa cytoplasmicdomain with one ITAMlike, and two ITIMlike motifs. FCRL proteins are differentiallyexpressed among B cells. FCRL2 is preferentially expressed on naïve and CD27+memory B cells within the spleen, lymph nodes, tonsils, and peripheral blood.It is also expressed on most B cells in B cell chronic lymphocytic leukemia (BCLL)patients. FCRL2 upregulation is associated with mutation of the immunoglobulinheavy chain variable (IGHV) and less aggressive forms of BCLL. |
Source : | Mammalian cells |
Form : | Lyophilized from a 0.2μm filtered solution in PBS. |
N-terminal Sequence : | Leu20 |
Molecular Weight : | 41.9 kDa |
Activity : | Measured by its abilityto bind human IgG with an estimated KD < 80 nM. |
Purity : | >95%, by SDS-PAGEunder reducing conditions and visualized by silver stain. |
Endotoxin Level : | <1.0 EU per 1 μg ofthe protein by the LAL method. |
Reconstitution : | Reconstitute at 100 μg/mLin sterile PBS. |
Storage : | Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution. |
OfficialSymbol : | FCRL2 |
Gene Name : | FCRL2 Fc receptor-like 2 [ Homosapiens ] |
Synonyms : | FCRL2; Fc receptor-like2; FCRH2; IFGP4; IRTA4; SPAP1; CD307b; SPAP1A; SPAP1B; SPAP1C; CD307b antigen;Fc receptor-like protein 2; fcR-like protein 2; IFGP family protein 4; fc receptorhomolog 2; immunoglobulin superfamily Fc receptor, gp42; SH2 domain containingphosphatase anchor protein 1; SH2 domain-containing phosphatase anchor protein1; immune receptor translocation-associated protein 4; immunoglobulin receptortranslocation-associated protein 4; OTTHUMP00000020928; OTTHUMP00000020931 |
Gene ID : | 79368 |
mRNA Refseq : | NM_030764 |
Protein Refseq : | NP_110391 |
MIM : | 606509 |
UniProt ID : | Q96LA5 |
Chromosome Location : | 1q21 |
Function : | SH3/SH2 adaptor activity;receptor activity |
Products Types
◆ Recombinant Protein | ||
FCRL2-4008H | Recombinant Human FCRL2 Protein, GST-tagged | +Inquiry |
FCRL2-2938H | Recombinant Human FCRL2 Protein, His (Fc)-Avi-tagged | +Inquiry |
FCRL2-1714R | Recombinant Rhesus Monkey FCRL2 Protein, hIgG4-tagged | +Inquiry |
FCRL2-1712R | Recombinant Rhesus Monkey FCRL2 Protein | +Inquiry |
FCRL2-1713R | Recombinant Rhesus Monkey FCRL2 Protein, hIgG1-tagged | +Inquiry |
◆ Lysates | ||
FCRL2-6275HCL | Recombinant Human FCRL2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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