Active Recombinant Human FUS Protein, Myc/DDK-tagged

• Cat.No.: FUS-06H
• Product Overview: Recombinant protein of human fusion (involved in t(12;16) in malignant liposarcoma) (FUS) with C-terminal Myc/DDK tag, expressed in HEK293T.

Specification

• Description: This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
• Source: HEK293T
• Species: Human
• Tag: Myc/DDK
• Bio-activity: Transmission electron microscopy; Co-immunoprecipitation; In vitro kinase assay inhibitor
• Molecular Mass: 53.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: FUS FUS RNA binding protein [ Homo sapiens (human) ]
• Official Symbol: FUS
• Synonyms: FUS; FUS RNA binding protein; TLS; ALS6; ETM4; FUS1; POMP75; altFUS; HNRNPP2; RNA-binding protein FUS; 75 kDa DNA-pairing protein
  fus-like protein; fused in sarcoma; fusion gene in myxoid liposarcoma; heterogeneous nuclear ribonucleoprotein P2; oncogene FUS; oncogene TLS; translocated in liposarcoma protein
• Gene ID: 2521
• mRNA Refseq: NM_004960
• Protein Refseq: NP_004951
• MIM: 137070
• UniProt ID: P35637