Description : |
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. |
Source : |
Insect cell |
Species : |
Human |
Tag : |
His |
Form : |
Sterile Filtered colorless solution |
Bio-activity : |
Specific activity is > 1600 pmol/min/ug and is defined as the amount of enzyme that hydrolyze 1.0 pmole of 4-Methylumbelliferone to 4- Methylum-belliferyl-β-D-glucosiduronic acid per minute at 37 centigrade and pH6.0. |
Molecular Mass : |
73.4 kDa |
AA Sequence : |
LQGGMLYPQESPSRECKELDGLWSF RADFSDNRRRGFEEQWYRRPLWESG PTVDMPVPSSFNDISQDWRLRHFVG WVWYEREVILPERWTQDLRTRVVLR IGSAHSYAIVWVNGVDTLEHEGGYL PFEADISNLVQVGPLPSRLRITIAI NNTLTPTTLPPGTIQYLTDTSKYPK GYFVQNTYFDFFNYAGLQRSVLLYT TPTTYIDDITVTTSVEQDSGLVNYQ ISVKGSNLFKLEVRLLDAENKVVAN GTGTQGQLKVPGVSLWWPYLMHERP AYLYSLEVQLTAQTSLGPVSDFYTL PVGIRTVAVTKSQFLINGKPFYFHG VNKHEDADIRGKGFDWPLLVKDFNL LRWLGANAFRTSHYPYAEEVMQMCD RYGIVVIDECPGVGLALPQFFNNVS LHHHMQVMEEVVRRDKNHPAVVMWS VANEPASHLESAGYYLKMVIAHTKS LDPSRPVTFVSNSNYAADKGAPYVD VICLNSYYSWYHDYGHLELIQLQLA TQFENWYKKYQKPIIQSEYGAETIA GFHQDPPLMFTEEYQKSLLEQYHLG LDQKRRKYVVGELIWNFADFMTEQS PTRVLGNKKGIFTRQRQPKSAAFLL RERYWKIANETRYPHSVAKSQCLEN SLFTHHHHHH |
Purity : |
Greater than 90.0% as determined by SDS-PAGE. |
Usage : |
This products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
Storage : |
Store at 4 centigrade if entire vial will be used within 2-4 weeks. Store, frozen at -20 centigrade for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
Storage Buffer : |
GUSB protein solution (0.25 mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |