Active Recombinant Human HDAC2, GST-tagged

• Cat.No.: HDAC2-1355H
• Product Overview: Full-length recombinant human HDAC2 was expressed by baculovirus in Sf9 insect cells using a C-terminal GST tag.

Specification

• Description: HDAC2 or Histone deacetylase 2 belongs to the histone deacetylase family that acts via the formation of large multiprotein complexes, and is responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). HDAC2 forms transcriptional repressor complexes by associating with many different proteins and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDAC2 functions in modulating synaptic plasticity and long-lasting changes of neural circuits, which in turn negatively regulates learning and memory. HDAC1 and HDAC2 are functionally redundant in cardiac growth and development and they maintain cardiomyocyte identity and function.
• Source: Sf9 Cells
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 4180 RLU/min/ng
• Molecular Mass: ~92 kDa
• Protein length: Full length
• Purity: >70%
• Applications: HDAC Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: HDAC2 histone deacetylase 2 [ Homo sapiens ]
• Official Symbol: HDAC2
• Synonyms: HDAC2; histone deacetylase 2; RPD3; YAF1; YY1-associated factor 1; transcriptional regulator homolog RPD3; HD2
• Gene ID: 3066
• mRNA Refseq: NM_001527
• Protein Refseq: NP_001518
• MIM: 605164
• UniProt ID: Q92769
• Chromosome Location: 6q21
• Pathway: Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem
• Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); chromatin binding; enzyme binding; histone deacetylase activity; histone deacetylase activity (H3-K16 specific); hydrolase activity; protein binding; protein deacetylase activity; sequence-specific DNA binding; transcription factor binding