Active Recombinant Human HSPA1A Protein, His-tagged

• Cat.No.: HSPA1A-015H
• Product Overview: Recombinant full length human HSPA1A protein (2-641) witha N-terminal Histidine-tag was purified from E. coli

Specification

• Description: HSPA4 heat shock protein family A (Hsp70) member 4 are abundant and stress-inducible 70 kDa molecular chaperone proteinsencoded by a highly conserved, multigene family. They are monomeric proteins that can be divided into two functional domains: an N-terminal ATPase domain and a substrate binding domain that contains a highly conserved EEVD motif at its C-terminus. Hsp70s are found in the cytosol, nuclei, endoplasmic reticulum, mitochondria, and chloroplasts of eukaryotes, as well as in bacteria. They function as molecular chaperones that assist in a wide range of cellular processes, including refolding of aggregated or misfolded proteins, co- and post-translational folding and assembly of nascent peptides, membrane translocation of secretory and organellar proteins, controlling activity of regulatory nuclear receptors, kinases and transcription factors, as well as acting cooperatively with the Hsp90 chaperone system in eukaryotes. The HSPA4 chaperone cycle is ATP-dependent and initiated by transient interaction of the HSPA4 substrate binding domain with hydrophobic regions within a peptide or protein.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 50 mM HEPES, pH 8.0, 150 mM sodium chloride, 1 mM DTT, and 10% glycerol
• Bio-activity: ATPase activity confirmed by ADP detection assay
• Molecular Mass: 71.7 kDa
• Protein length: 2-641
• Purity: ≥75% estimated by SDS-PAGE
• Stability: ≥ 1 year
• Storage: Store at -80 centigrade
• Shipping: Dry ice in continental US; may vary elsewhere

Gene Information

• Gene Name: HSPA1A heat shock protein family A (Hsp70) member 1A [ Homo sapiens (human) ]
• Official Symbol: HSPA1A
• Synonyms: HSPA1A; heat shock protein family A (Hsp70) member 1A; HSP72; HSPA1; HSP70I; HSP70-1; HSP70-2; HSP70.1; HSP70.2; HSP70-1A; HEL-S-103; heat shock 70 kDa protein 1A; HSP70-1/HSP70-2; HSP70.1/HSP70.2; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; dnaK-type molecular chaperone HSP70-1; epididymis secretory protein Li 103; epididymis secretory sperm binding protein; heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; heat shock 70 kDa protein 1A/1B; heat shock 70kD protein 1A; heat shock 70kDa protein 1A; heat shock-induced protein
• Gene ID: 3303
• mRNA Refseq: NM_005345
• Protein Refseq: NP_005336
• MIM: 140550
• UniProt ID: P0DMV8