Active Recombinant Human IDS Protein, His-tagged

• Cat.No.: IDS-017H
• Product Overview: Active recombinant human C-terminal His-tagged IDS protein (26-550) was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized
• Bio-activity: Measured by its ability to hydrolyze the substrate 4-nitrocatechol sulfate (PNCS). The specific activity is > 1.0 pmoles/min/ μg.
• Molecular Mass: 61 kDa
• Protein length: 26-550
• Endotoxin: <1.0 EU/ μg, determined by the LAL endotoxin assay.
• Purity: ≥87% estimated by SDS-PAGE
• Stability: ≥ 2 years
• Storage: At -80 centigrade.
• Storage Buffer: Sterile PBS, pH 7.4

Gene Information

• Gene Name: IDS iduronate 2-sulfatase [ Homo sapiens (human) ]
• Official Symbol: IDS
• Synonyms: IDS; iduronate 2-sulfatase; ID2S; MPS2; SIDS; iduronate 2-sulfatase; alpha-L-iduronate sulfate sulfatase; iduronate 2-sulfatase 14 kDa chain; iduronate 2-sulfatase 42 kDa chain; idursulfase; EC 3.1.6.13
• Gene ID: 3423
• mRNA Refseq: NM_000202
• Protein Refseq: NP_000193
• MIM: 300823
• UniProt ID: P22304