Active Recombinant Human IGF1R(959-end) Protein, N-His-tagged
Cat.No. : | IGF1R-107H |
Product Overview : | N-terminal 6Histagged, recombinant human IGF-1R residues 959–end, expressed by baculovirus in Sf21 insect cells. |
- Specification
- Gene Information
- Related Products
Description : | Insulin-like growth factor (IGF) binding to the IGF receptors initiates an intracellular signaling cascade that leads to changes in gene expression and cell biology. Although multiple receptors for the IGFs have been identified, the IGFs primarily exert their biologic effects through ligation of the IGF1R (type I IGF receptor tyrosine kinase, JTK13). IGF1R exerts mitogenic, cell survival, and insulin-like activities, is involved in postnatal growth physiology, and is connected to proliferative disorders such as breast cancer. |
Source : | Sf21 |
Species : | Human |
Tag : | His |
Protein length : | 959-end |
Form : | 2.03mg/ml of enzyme in 50mM Tris/HCl pH7.5, 150mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mMPMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution |
Bio-activity : | 97U/mg, where one unit of IGF-1R activity is defined as 1nmol phosphate incorporated into 250μM (KKKSPGEYVNIEFG) per minute at 30 centigrade with a final ATP concentration of 100μM. |
Molecular Mass : | 48 kDa |
AA Sequence : | 1 MAHHHHHHEN LYFQGHRKRN NSRLGNGVLY ASVNPEYFSA ADVYVPDEWE VAREKITMSR 61 ELGQGSFGMV YEGVAKGVVK DEPETRVAIK TVNEAASMRE RIEFLNEASV MKEFNCHHVV 121 RLLGVVSQGQ PTLVIMELMT RGDLKSYLRS LRPEMENNPV LAPPSLSKMI QMAGEIADGM 181 AYLNANKFVH RDLAARNCMV AEDFTVKIGD FGMTRDIYET DYYRKGGKGL LPVRWMSPES 241 LKDGVFTTYS DVWSFGVVLW EIATLAEQPY QGLSNEQVLR FVMEGGLLDK PDNCPDMLFE 301 LMRMCWQYNP KMRPSFLEII SSIKEEMEPG FREVSFYYSE ENKLPEPEEL DLEPENMESV 361 PLDPSASSSS LPLPDRHSGH KAENGPGPGV LVLRASFDER QPYAHMNGGR KNERALPLPQ 421 SSTC |
Purity : | Purity 78% by SDS-PAGE and Coomassie blue staining. |
Applications : | Drug Discovery & Development |
Storage : | 6 months at -70 centigrade. |
Handling Advice : | Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into prechilled micro-centrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70 centigrade. |
Use/Stability : | On receipt of material store at -70 centigrade. Unopened reagent is stable for a minimum of 1 year from date of shipment when stored at recommended storage temperature. Avoid repeat freeze/thaw cycles. For maximum recovery of product, centrifuge original vial prior to removing the cap. |
Gene Name : | IGF1R insulin like growth factor 1 receptor [ Homo sapiens (human) ] |
Official Symbol : | IGF1R |
Synonyms : | IGF1R; insulin like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13 |
Gene ID : | 3480 |
mRNA Refseq : | NM_000875.5 |
Protein Refseq : | NP_000866.1 |
MIM : | 147370 |
UniProt ID : | P08069 |
Products Types
◆ Recombinant Protein | ||
IGF1R-299H | Recombinant Human IGF1R Protein, His and Strep-tagged | +Inquiry |
IGF1R-1154H | Recombinant Human IGF1R Protein, His (Fc)-Avi-tagged | +Inquiry |
Igf1r-1223M | Recombinant Mouse Igf1r Protein, MYC/DDK-tagged | +Inquiry |
IGF1R-0996H | Recombinant Human IGF1R Protein (S982-K1286), Tag Free | +Inquiry |
IGF1R-0995H | Recombinant Human IGF1R Protein (S982-K1286), His tagged | +Inquiry |
◆ Lysates | ||
IGF1R-2928HCL | Recombinant Human IGF1R cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1601 | HEK 293 IGF1R Bioassay Kit | +Inquiry |
Kit-1600 | IGF1R Functional Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket