| Description : |
IGF-BP-2,also known as Insulin-like growth factor-binding protein 2, IBP-2 and BP-2, is a cysteine-rich secreted protein belonging to the IGF-binding protein superfamily. It is expressed by the central nervous system, bone cells and reproductive tissues. IGF-BP-2 binds to both IGF-I and IGF-II, with a much higher binding affinity to IGF-II than IGF-I. IGF-BP-2 has been shown to inhibitand stimulate the growth promoting effects of IGFs, thus serving as a regulator for IGF distribution, function and activity. |
| Source : |
HEK 293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Sterile Filtered White lyophilized (freeze-dried) powder. |
| Bio-activity : |
ED50 < 2 μg/mL, measured in a bioassay using FDC-P1 cells in the presence of 15 ng/mL human IGF-II. |
| Molecular Mass : |
6-20 kDa, observed by reducing SDS-PAGE. |
| AA Sequence : |
FRCPPCTPERLAACGPPPVAPPAAV AAVAGGARMPCAELVREPGCGCCSV CARLEGEACGVYTPRCGQGLRCYPH PGSELPLQALVMGEGTCEKRRDAEY GASPEQVADNGDDHSEGGLVENHVD STMNMLGGGGSAGRKPLKSGMKELA VFREKVTEQHRQMGKGGKHHLGLEE PKKLRPPPARTPCQQELDQVLERIS TMRLPDERGPLEHLYSLHIPNCDKH GLYNLKQCKMSLNGQRGECWCVNPN TGKLIQGAPTIRGDPECHLFYNEQQ EARGVHTQRMQHHHHHH |
| Endotoxin : |
< 0.2 EU/μg, determined by LAL method. |
| Purity : |
> 95% as analyzed by SDS-PAGE. |
| Storage : |
Lyophilized recombinant human IGF-BP-2, Hisremains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, human IGF-BP-2, His should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade. |
| Storage Buffer : |
Lyophilized after extensive dialysis against PBS. |
| Reconstitution : |
Reconstituted in ddH2O or PBS at 100 μg/mL. |
