Active Recombinant Human IGFBP3, Met-tagged
Cat.No. : | IGFBP3-489H |
Product Overview : | Recombinant Human IGFBP3 (Accession # CAA46087) Gly28-Lys291, fused with an N-terminal Met, was produced in Mouse myeloma cell line, NS0-derived. |
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Source : | Mammalian cells |
Species : | Human |
Predicted N Terminal : | Met |
Form : | Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA. |
Bio-activity : | Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on MCF-7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083.The ED50 for this effect is typically 0.05 - 0.15 µg/mL in the presence of 14 ng/mL rhIGF-II. |
Molecular Mass : | Recombinant Human IGFBP3, Met-tagged has a calculated MW of 29 kDa. In SDS-PAGE migrates as 41 kDa, reducing conditions. |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Gene Name : | IGFBP3 insulin-like growth factor binding protein 3 [ Homo sapiens ] |
Official Symbol : | IGFBP3 |
Synonyms : | IGFBP3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3; acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP 53; growth hormone dependent binding protein; IBP3; IGF binding protein 3; IBP-3; IGFBP-3; IGF-binding protein 3; growth hormone-dependent binding protein; BP-53; |
Gene ID : | 3486 |
mRNA Refseq : | NM_000598 |
Protein Refseq : | NP_000589 |
MIM : | 146732 |
UniProt ID : | P17936 |
Chromosome Location : | 7p13-p12 |
Products Types
◆ Recombinant Protein | ||
IGFBP3-12H | Recombinant Human IGFBP3 Protein (28-291aa), N-His-tagged | +Inquiry |
IGFBP3-2678H | Recombinant Human IGFBP3 protein(121-200 aa), C-His-tagged | +Inquiry |
Igfbp3-1655M | Recombinant Mouse Igfbp3 Protein, His-tagged | +Inquiry |
IGFBP3-758H | Recombinant Human IGFBP3 protein(Gly28-Lys291), His-tagged | +Inquiry |
IGFBP3-110I | Active Recombinant Human IGFBP3 Protein (264 aa) | +Inquiry |
◆ Lysates | ||
IGFBP3-2927HCL | Recombinant Human IGFBP3 cell lysate | +Inquiry |
IGFBP3-1230CCL | Recombinant Cynomolgus IGFBP3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, genetic variations can affect IGFBP3 expression, potentially leading to differences in protein levels among individuals.
IGFBP3 is involved in bone metabolism and is associated with bone mineral density. Low levels of IGFBP3 have been linked to decreased bone density and increased risk of fractures.
The potential side effects of therapies targeting IGFBP3 are still being studied, and it varies depending on the specific treatment approach being used.
Healthy lifestyle choices, including a balanced diet and regular exercise, can positively influence IGFBP3 levels, promoting overall health and reducing the risk of related diseases.
IGFBP3 deficiency can impact children's growth and development, potentially leading to short stature and delayed puberty, as IGFBP3 is a key regulator of growth hormone actions.
Customer Reviews (3)
Write a reviewA manufacturer that offers customization options can enable the researcher to adhere to their experimental design requirements more effectively.
A reliable manufacturer should be able to provide a consistently pure and high-quality IGFBP3 protein, ensuring that the samples are suitable for research purposes.
This can help ensure compatibility between different components used in the trials and ease the overall experimental workflow.
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