Active Recombinant Human Insulin-Like 3 (Leydig cell)
Cat.No. : | INSL3-384H |
Product Overview : | RecombinantHuman INSL3 protein was expressed in E. coli. Ala106-Tyr131(A chain) & Leu21-Ala55. |
- Specification
- Gene Information
- Related Products
Cat. No. : | INSL3-384H |
Description : | INSL3 isa member of the insulin/relaxin superfamily. INSL3 is a secreted proteinproduced in high amounts by testicular Leydig cells, and in lower amounts by ovarianfollicular theca interna cells. As with other insulin/relaxin superfamilymembers, human INSL3 is synthesized as a preprohormone. The Prepro INSL3precursor is 131 amino acids (aa) in length. It is processed by a prohormoneconvertase to remove a 20 aa signal sequence and a 47 aa internal pro-, or C-peptidethat separates a 35 aa N-terminal B chain from a 26 aa C-terminal A chain. |
Source : | E. coli |
Form : | Lyophilizedfrom a 0.2 um filtered solution in PBS. |
N-terminalSequence : | Ala106 (A chain)& Leu21(B chain) |
MolecularWeight : | 2.8 kDa (A chain),3.3 kDa (B chain) |
Activity : | Measuredby its ability to induce cAMP accumulation in human RXFP2 transfected HEK293human embryonic kidney cells. The ED50 for this effect is typically 12.5-50 pg/mL. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
Purity : | >95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | Reconstituteat 100μg/mL in sterile PBS. |
Storage : | Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months,-20 to -70°C under sterile conditions after reconstitution. |
Gene Name : | INSL3 insulin-like 3 (Leydigcell) [ Homo sapiens ] |
Official Symbol : | INSL3 |
Synonyms : | INSL3; insulin-like3 (Leydig cell); RLF; RLNL; insulin-like 3; ley-I-L; relaxin-likefactor b; leydig insulin-like peptide; leydig insulin -like hormone |
Gene ID : | 3640 |
mRNA Refseq : | NM_005543 |
Protein Refseq : | NP_005534 |
MIM : | 146738 |
UniProt ID : | P51460 |
Chromosome Location : | 19p13.2-p12 |
Pathway : | Class A/1 (Rhodopsin-like receptors);Cytokine Signaling in Immune system; G alpha (s) signalling events; GPCRdownstream signaling; GPCR ligand binding; Immune System; Interleukinreceptor SHC signaling; Interleukin-2 signaling; Interleukin-3, 5 and GM-CSFsignaling; Interleukin-7 signaling; Peptide ligand-binding receptors; Relaxinreceptors; Signal Transduction; Signaling by GPCR; Signaling by Interleukins |
Function : | G-protein coupled receptor binding; hormoneactivity; insulin receptor binding; receptor binding |
Products Types
◆ Recombinant Protein | ||
INSL3-2101R | Recombinant Rhesus Macaque INSL3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Insl3-1062R | Recombinant Rat Insl3 Protein, His&SUMO-tagged | +Inquiry |
Insl3-3553M | Recombinant Mouse Insl3 Protein, Myc/DDK-tagged | +Inquiry |
INSL3-2736R | Recombinant Rat INSL3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Insl3-1048R | Recombinant Rat Insl3 protein, His & GST-tagged | +Inquiry |
◆ Lysates | ||
INSL3-5191HCL | Recombinant Human INSL3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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