Active Recombinant Human Insulin-like Growth Factor 1
Cat.No. : | IGF1-658H |
Product Overview : | IGF1 Des(1-3) Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 67 amino acids (aa 4-70) and having a molecular mass of 7372 Dalton. IGF-1 Des1-3 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IGF1-658H |
Description : | The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed "sulfation factor," which later became known as "somatomedin". Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190). |
Source : | Human |
Host : | Escherichia Coli. |
Form : | The protein was lyophilized after extensive dialysis against 50mM acetic acid buffer. |
Purity : | Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Bio-activity : | The ED50, calculated by the dose-dependant proliferation of murine BALB\C 3T3 cells (measured by 3H-thymidine uptake) is < 1.0 ng/ml, corresponding to a specific activity of 1x106 U/mg. For most in-vitro applications, IGF1 des1-3 exerts its biological activity in the concentration range of 0.2-20 ng/ml. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Solubility : | It is recommended to reconstitute the lyophilized IGF1 Des(1-3) in 100mM Acetic acid not less than 100μg/ml, which can then be further diluted to other aqueous solutions. |
Amino acid sequence : | The sequence of the first five N-terminal amino acids was determined and was found to be Thr-Leu-Cys-Gly-Ala. |
Storage : | Lyophilized IGF1 des(1-3) although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGF1 des-1-3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | IGF1 insulin-like growth factor 1 (somatomedin C) [ Homo sapiens ] |
Official Symbol : | IGF1 |
Synonyms : | IBP1; IGF-I; IGF-IA; IGFI; MGF; Somatomedin-C; Mechano growth factor; insulin-like growth factor 1; insulin-like growth factor 1 (somatomedin C); somatomedin C; IGF1B_HUMAN; Insulin-like growth factor IB [Precursor]; IGF-IB. |
Gene ID : | 3479 |
mRNA Refseq : | NM_000618 |
Protein Refseq : | NP_000609 |
MIM : | 608747 |
UniProt ID : | P01343 |
Chromosome Location : | 12q23.2 |
Pathway : | Focal adhesion; Glioma; Long-term depression; Melanoma; Prostate cancer; mTOR signaling pathway; Hemostasis |
Function : | Growth factor activity; Hormone activity; Hormone activity; Insulin receptor binding; Insulin-like growth factor receptor binding; Protein binding |
Products Types
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Igf1-080M | Active Recombinant Mouse Igf1 Protein | +Inquiry |
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◆ Lysates | ||
IGF1-5268HCL | Recombinant Human IGF1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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