Active Recombinant Human JAG1, Fc-tagged
Cat.No. : | JAG1-380H |
Product Overview : | Signal peptide and extracellular domain of human Jagged-1 (HJ1; CD339) (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG1. |
- Specification
- Gene Information
- Related Products
Description : | Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF). |
Source : | HEK293 Cells |
Species : | Human |
Tag : | Fc |
Form : | Liquid. 0.2μm-filtered solution in PBS. |
Bio-activity : | Inhibits adipogenesis of mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells. |
Molecular Mass : | ~150kDa (SDS-PAGE) |
Purity : | ≥90% (SDS-PAGE) |
Stability : | Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
Concentration : | 0.5mg/ml |
Gene Name : | JAG1 jagged 1 [ Homo sapiens ] |
Official Symbol : | JAG1 |
Synonyms : | JAG1; jagged 1; AGS, Alagille syndrome , JAGL1; protein jagged-1; AHD; AWS; CD339; HJ1; AGS; JAGL1; MGC104644; |
Gene ID : | 182 |
mRNA Refseq : | NM_000214 |
Protein Refseq : | NP_000205 |
UniProt ID : | P78504 |
Chromosome Location : | 20p12.1-p11.23 |
Pathway : | Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, conserved biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem; |
Function : | Notch binding; calcium ion binding; growth factor activity; structural molecule activity; |
Products Types
◆ Recombinant Protein | ||
JAG1-344H | Recombinant Human JAG1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Jag1-1705R | Recombinant Rat Jag1 Protein, His-tagged | +Inquiry |
Jag1-3625M | Recombinant Mouse Jag1 Protein, Myc/DDK-tagged | +Inquiry |
JAG1-1226H | Recombinant Human JAG1 Protein, His (Fc)-Avi-tagged | +Inquiry |
JAG1-792H | Recombinant Human JAG1 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
JAG1-2382HCL | Recombinant Human JAG1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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