Active Recombinant Human KIAA1804, GST-tagged
Cat.No. : | KIAA1804-85H |
Product Overview : | Recombinant human MLK4 (1-557) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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Description : | MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas. MLK4 is a negative regulator of TLR4. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | The specific activity of MLK4 was determined to be 22 nmol/min/mg as per activity assay protocol. |
Molecular Mass : | ?~61 kDa |
AA Sequence : | 1-557 |
Purity : | The purity of MLK4 was determined to be >80% by densitometry, approx. |
Applications : | Kinase Assay; Western Blot |
Stability : | 1 yr at –70oC from date of shipment. |
Storage : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 ug/ul |
Gene Name : | KIAA1804?mixed lineage kinase 4 [?Homo sapiens?(human) ] |
Official Symbol : | KIAA1804 |
Synonyms : | KIAA1804; MLK4; dJ862P8.3; RP5-862P8.2; mixed lineage kinase 4; mitogen-activated protein kinase kinase kinase MLK4; EC 2.7.11.25 |
Gene ID : | 84451 |
mRNA Refseq : | NM_032435 |
Protein Refseq : | NP_115811 |
MIM : | 614793 |
UniProt ID : | Q5TCX8 |
Chromosome Location : | 1q42 |
Function : | ATP binding; MAP kinase kinase kinase activity; protein homodimerization activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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