Active Recombinant Human Left-right Determination Factor 1

• Cat.No.: Lefty1-1915H
• Product Overview: Recombinant Human Left-right Determination Factor 1 was expressed inhuman 293 cells.

Specification

• Cat. No.: LEFTY1-1915H
• Description: Lefty (left-right determination factors) are proteins that are closely related members of the TGF-beta family of growth factors. These proteins are secreted and play a role in left-right asymmetry determination of organ systems during development. Mutations of the genes encoding these proteins have been associated with left-right axis malformations, particularly in the heart and lungs.
• Source: Human 293 cells.
• Activity: 10 to 40 ng/mL ED50.
• Purity: >90%.
• Endotoxin: Endotoxin-free.
• Molecular Mass: 38 kDa, monomer, glycosylated.
• Purity Confirmation: The protein was resolved by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.
• Activity Assay: The specific activity was determined by dose dependent ability to inhibit BMP-4 (6.5 ng/mL) induction of alkaline phosphatase production in the MC-3T3-E1 cell line (Mouse chondrogenic cell line).

Gene Information

• Gene Name: LEFTY1 left-right determination factor 1 [ Homo sapiens ]
• Synonyms: LEFTB; LEFTYB; LEFTY1; left-right determination factor 1; left-right determination, factor B; Protein lefty-1; Left-right determination factor B; Protein lefty-B; UNQ278/PRO317
• Gene ID: 10637
• mRNA Refseq: NM_020997
• Protein Refseq: NP_066277
• MIM: 603037
• UniProt ID: O75610
• Chromosome Location: 1q42.1
• Pathway: TGF-beta signaling pathway
• Function: cytokine activity; growth factor activity; transforming growth factor beta receptor binding

Reviews

02/12/2021

The knowledgeable and experienced support team is readily available to address any questions or concerns that researchers may have throughout their experimental journey.

08/22/2018

Its stability and reliability warrant its inclusion in my research protocols, leading to meaningful and conclusive results.

10/02/2016

Their prompt and effective responses help ensure smooth and efficient progress, indeed solving any problem that arises.

Q&As

Can LEFTY1 be used in combination with other treatments?

Combination therapies involving LEFTY1 are being investigated to enhance treatment efficacy and reduce the risk of resistance development.

Are there any ongoing clinical trials involving LEFTY1?

Some clinical trials are exploring the therapeutic potential of LEFTY1, particularly in cancer treatment and tissue regeneration.

How does LEFTY1 interact with other signaling pathways in the body?

LEFTY1 interacts with various signaling pathways, influencing cellular processes involved in development, immune response, and disease progression.

How is LEFTY1 protein associated with clinical applications?

LEFTY1 has shown potential clinical applications in various fields, including cancer research and regenerative medicine.

How does LEFTY1 contribute to tissue regeneration?

LEFTY1 has demonstrated the ability to influence stem cell differentiation and tissue repair, making it a potential candidate for regenerative medicine.