Active Recombinant Human MAP2K4, His-tagged

• Cat.No.: MAP2K4-105H
• Product Overview: Human MKK4, full length, amino acids M1-D399 (as in NCBI/Protein entry NP_003001.1), activated, N-terminal HIS6 fusion protein with a Thrombin cleavage site, expressed in Sf9 insect cells

Specification

• Description: MAP2K4 encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. MAP2K4 is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1. MAP2K4 is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
• Source: Baculovirus infected Sf9
• Species: Human
• Tag: His
• Form: 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 20% glycerol
• Bio-activity: 41 pmol/μg×min
• Storage: Store at -80°C. Avoid repeated freeze-thaw cycles!
• Concentration: 0.884 μg/μl

Gene Information

• Gene Name: MAP2K4 mitogen-activated protein kinase kinase 4 [ Homo sapiens ]
• Official Symbol: MAP2K4
• Synonyms: MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; dual specificity mitogen-activated protein kinase kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; MAP kinase kinase 4; JNK-activated kinase 1; JNK activating kinase 1; JNK-activating kinase 1; c-Jun N-terminal kinase kinase 1; stress-activated protein kinase kinase 1; JNKK; SEK1; MAPKK4; SAPKK1; SAPKK-1
• Gene ID: 6416
• mRNA Refseq: NM_003010
• Protein Refseq: NP_003001
• MIM: 601335
• UniProt ID: P45985
• Chromosome Location: 17p12
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Apoptosis, organism-specific biosystem; CD40/CD40L signaling, organism-specific biosystem; CDC42 signaling events, organism-specific biosystem; Cellular roles of Anthrax toxin, organism-specific biosystem; Ceramide signaling pathway, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity

Reviews

10/25/2021

Good value, high quality.

04/03/2021

Pure product, no issues.

03/13/2021

Reliable, worked as described.

Q&As

Are there existing or potential therapeutic strategies targeting MAP2K4?

Targeting MAP2K4 may provide therapeutic benefits in cancer, modulating cell survival and response to stress.

What role does MAP2K4 play in cellular stress response?

MAP2K4 helps cells respond to stress, modulating survival and death pathways.

How is MAP2K4 implicated in cancer development and progression?

Dysregulation of MAP2K4 has been linked to cancer, affecting cell growth and resistance to apoptosis.

How does MAP2K4 contribute to the JNK and p38 MAPK pathways?

It phosphorylates and activates JNK and p38, transmitting signals in response to stress.

How is the activity of MAP2K4 regulated within cells?

Its activity is regulated by phosphorylation and interaction with other signaling proteins.

In which cellular processes is MAP2K4 involved?

MAP2K4 is involved in processes like cell growth, apoptosis, and stress response.

What is the primary biological function of MAP2K4 in cellular signaling?

MAP2K4 is a kinase that plays a critical role in activating the JNK and p38 MAPK signaling pathways.