Active Recombinant Human MICA Protein, His-tagged
Cat.No. : | MICA-03H |
Product Overview : | Recombinant human MICA, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid |
Bio-activity : | Measured by its binding ability in a functional ELISA with Human NKG2D. |
Molecular Mass : | 32.7 kDa (283aa) confirmed by MALDI-TOF |
AA Sequence : | MEPHSLRYNLTVLSWDGSVQSGFLT EVHLDGQPFLRCDRQKCRAKPQGQW AEDVLGNKTWDRETRDLTGNGKDLR MTLAHIKDQKEGLHSLQEIRVCEIH EDNSTRSSQHFYYDGELFLSQNLET EEWTMPQSSRAQTLAMNVRNFLKED AMKTKTHYHAMHADCLQELRRYLKS GVVLRRTVPPMVNVTRSEASEGNIT VTCRASGFYPWNITLSWRQDGVSLS HDTQQWGDVLPDGNGTYQTWVATRI CQGEEQRFTCYMEHSGNHSTHPVPS |
Endotoxin : | < 1 EU/μg of protein (determined by LAL method) |
Purity : | > 90% by SDS-PAGE |
Applications : | SDS-PAGE, Bioactivity |
Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/mL (determined by Bradford assay) |
Storage Buffer : | 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol |
Gene Name : | MICA MHC class I polypeptide-related sequence A [ Homo sapiens (human) ] |
Official Symbol : | MICA |
Synonyms : | MICA; MHC class I polypeptide-related sequence A; MIC-A; PERB11.1; MHC class I polypeptide-related sequence A; HLA class I antigen; MHC class I chain-related protein A; MHC class I related chain A; MHC class I related sequence A; major histocompatibility complex class I chain-related protein A; stress inducible class I homolog |
Gene ID : | 100507436 |
mRNA Refseq : | NM_000247 |
Protein Refseq : | NP_000238 |
MIM : | 600169 |
UniProt ID : | Q29983 |
Products Types
◆ Recombinant Protein | ||
MICA-706H | Active Biotinylated Recombinant Human MICA Protein (Ala23-Gln308), Fc/Avi tagged | +Inquiry |
MICA-5319H | Recombinant Human MICA Protein, GST-tagged | +Inquiry |
MICA-202H | Recombinant Human MICA Protein, His (Fc)-Avi-tagged | +Inquiry |
MICA-1235H | Recombinant Human MICA Protein, MYC/DDK-tagged | +Inquiry |
MICA-823H | Recombinant Human MICA Protein | +Inquiry |
◆ Lysates | ||
MICA-1941HCL | Recombinant Human MICA cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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