Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 555 conjugated
Cat.No. : | MSLN-10625HAF555 |
Product Overview : | Alexa Fluor 555 conjugated recombinant human MSLN-Fc fusion protein is expressed as a 534-amino acid protein consisting of Glu296 - Ser592 region of MSLN (UniProt accession #Q13421, isoform 2) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions. |
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Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Bio-activity : | Binds to CA125/MUC16 and anti-MSLN monoclonal antibody, human IgG1 with high affinity. Blocks MSLN's binding to CA125/MUC16. |
Molecular Mass : | Calculated molecular mass (kDa): 60.1; Estimated by SDS-PAGE under reducing condition (kDa): 65-70 |
AA Sequence : | EVEKTACPSGKKAREIDESLIFYKK WELEACVDAALLATQMDRVNAIPFT YEQLDVLKHKLDELYPQGYPESVIQ HLGYLFLKMSPEDIRKWNVTSLETL KALLEVNKGHEMSPQVATLIDRFVK GRGQLDKDTLDTLTAFYPGYLCSLS PEELSSVPPSSIWAVRPQDLDTCDP RQLDVLYPKARLAFQNMNGSEYFVK IQSFLGGAPTEDLKALSQQNVSMDL ATFMKLRTDAVLPLTVAEVQKLLGP HVEGLKAEERHRPVRDWILRQRQDD LDTLGLGLQGGIPNGYLVLDLSTTE NLYFQGSTGTHTCPPCPAPELLGGP SVFLFPPKPKDTLMISRTPEVTCVV VDVSHEDPEVKFNWYVDGVEVHNAK TKPREEQYNSTYRVVSVLTVLHQDW LNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQV SLTCLVKGFYPSDIAVEWESNGQPE NNYKTTPPVLDSDGSFFLYSKLTVD KSRWQQGNVFSCSVMHEALHNHYTQ KSLSLSPGK |
Endotoxin : | < 0.1 EU/ μg of purified recombinant protein determined by the LAL method |
Purity : | > 95 % by SDS-PAGE under reducing condition |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 555 via amines With an excitation and emission maximum of 555/565 nm, Alexa Fluor 555 can be efficiently excited using a 543 nm He-Ne laser line and detected under standard TRITC/Cy3 filters. |
Storage : | The product is shipped at 4 centigrade. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20 centigrade for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4 centigrade for no more than 2 weeks. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied at 0.5 mg/ml in sterile PBS pH 7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule) using the standard procedure. |
Gene Name : | MSLN |
Official Symbol : | MSLN |
Synonyms : | Mesothelin; MPF; SMRP; MSLN; mesothelin; CAK1 antigen; megakaryocyte potentiating factor; pre-pro-megakaryocyte-potentiating factor; soluble MPF mesothelin related protein |
Gene ID : | 10232 |
mRNA Refseq : | NM_005823 |
Protein Refseq : | NP_005814 |
MIM : | 601051 |
UniProt ID : | Q13421 |
Products Types
◆ Lysates | ||
MSLN-1316HCL | Recombinant Human MSLN cell lysate | +Inquiry |
MSLN-1343HCL | Recombinant Human MSLN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.
In cancer, MSLN expression is significantly upregulated.
MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.
Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.
MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.
MSLN overexpression is often associated with poor prognosis in cancer patients.
MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.
Customer Reviews (3)
Write a reviewVery satisfied, great product.
Product is high-quality.
Excellent for experiments, reliable.
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