Active Recombinant Human NRG4
Cat.No. : | NRG4-525H |
Product Overview : | Recombinant human Neuregulin-4 EGF domain is a disulfide-linked monomeric protein consisting of 62 amino acid residue subunits, and migrates as an approximately 7 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Neuregulin-4 EGF domain was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Neuregulins (NDF, heregulin, GGF ARIA, or SMDF) are EGF- like growth and differentiation factors that signal through tyrosine kinase receptors of the ErbB family. The ErbB2 and ErbB4 receptors cooperate in transmission of neuregulin-1 signals in the heart, whereas ErbB2 and ErbB3 cooperate in neural crest cells. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized from a 0.2 µm filtered 20 mM phosphate buffer, pH 6.0. |
Bio-activity : | The ED50 was determined by the phosphorylation of ErbB2 and ErbB4 receptors in CHO cells, and was found to be <3ng/ml, corresponding to a specific activity of 3x 10^5 Units/mg. |
Molecular Mass : | 7 kDa |
AA Sequence : | HEEPCGPSHKSFCLNGGLCYVIPTI PSPFCRCVENYTGARCEEVFLPGSS IQTKSNLFEAF |
Endotoxin : | <0.1 ng/µg (1 EU/µg), using the LAL gel clot method. |
Purity : | ≥96% by SDS-PAGE and HPLC |
Stability : | The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20 centigrade. Upon reconstitution, store in working aliquots at +4 centigrade for up to one month, or at -20 centigrade for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles. |
Reconstitution : | Reconstitute at 0.1-1.0 mg/ml in distilled water. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid. |
Gene Name : | NRG4 neuregulin 4 [ Homo sapiens ] |
Official Symbol : | NRG4 |
Synonyms : | HRG4; pro-neuregulin-4, membrane-bound isoform; heregulin 4; pro-NRG4 |
Gene ID : | 145957 |
mRNA Refseq : | NM_138573 |
Protein Refseq : | NP_612640 |
MIM : | 610894 |
UniProt ID : | Q8WWG1 |
Chromosome Location : | 15q24.2 |
Pathway : | Adaptive Immune System, organism-specific biosystem; DAP12 interactions, organism-specific biosystem; ErbB receptor signaling network, organism-specific biosystem |
Function : | growth factor activity; protein binding; receptor binding |
Products Types
◆ Recombinant Protein | ||
Nrg4-366M | Recombinant Mouse Nrg4 Protein, His-tagged | +Inquiry |
NRG4-167 | Recombinant NRG4 Protein, GST-tagged | +Inquiry |
NRG4-07H | Active Recombinant Human NRG4 Protein | +Inquiry |
NRG4-6200M | Recombinant Mouse NRG4 Protein, His (Fc)-Avi-tagged | +Inquiry |
NRG4-825H | Recombinant Human NRG4 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
NRG4-1221HCL | Recombinant Human NRG4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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