Active Recombinant Human NTRK1 Protein

• Cat.No.: NTRK1-163N
• Product Overview: Recombinant Human NTRK1 Protein without tag was expressed in HEK 293.

Specification

• Description: Tyrosine kinase receptor A (Trk-A) is a member of the neurotrophic tyrosine kinase receptor family which includes three members: Trk-A, Trk-B and Trk-C. Trk-A is involved in the development and maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic neurons.
• Source: HEK 293
• Species: Human
• Form: Sterile Filtered White lyophilized (freeze-dried) powder.
• Bio-activity: ED50 < 1 μg/mL, measured in a neutralization assay in the presence of 10 ng/mL human β-NGF using TF-1 Cells.
• Molecular Mass: 65~85 kDa, observed by reducing SDS-PAGE.
• AA Sequence: APCPDACCPHGSSGLRCTRDGALDS LHHLPGAENLTELYIENQQHLQHLE LRDLRGLGELRNLTIVKSGLRFVAP DAFHFTPRLSRLNLSFNALESLSWK TVQGLSLQELVLSGNPLHCSCALRW LQRWEEEGLGGVPEQKLQCHGQGPL AHMPNASCGVPTLKVQVPNASVDVG DDVLLRCQVEGRGLEQAGWILTELE QSATVMKSGGLPSLGLTLANVTSDL NRKNVTCWAENDVGRAEVSVQVNVS FPASVQLHTAVEMHHWCIPFSVDGQ PAPSLRWLFNGSVLNETSFIFTEFL EPAANETVRHGCLRLNQPTHVNNGN YTLLAANPFGQASASIMAAFMDNPF EFNPEDPIPVSFSPVDTNSTSGDP
• Endotoxin: < 0.2 EU/μg, determined by LAL method.
• Purity: > 95% as analyzed by SDS-PAGE.
• Storage: Lyophilized recombinant Human Tyrosine kinase receptor A remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, Human Tyrosine kinase receptor A should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.
• Storage Buffer: Lyophilized after extensive dialysis against PBS.
• Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Gene Information

• Gene Name: NTRK1 neurotrophic receptor tyrosine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: NTRK1
• Synonyms: NTRK1; neurotrophic receptor tyrosine kinase 1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; high affinity nerve growth factor receptor; Oncogene TRK; TRK1-transforming tyrosine kinase protein; gp140trk; neurotrophic tyrosine kinase, receptor, type 1; tropomyosin-related kinase A; tyrosine kinase receptor A; EC 2.7.10.1
• Gene ID: 4914
• mRNA Refseq: NM_002529
• Protein Refseq: NP_002520
• MIM: 191315
• UniProt ID: P04629